Частоты аллелей в популяциях России и мира

Катехол-O-метилтрансфераза COMT

Val158Met

rs4680

 

Публикации:

Inglehart R.F., Borinskaya S., Cotter A., Harro J, Inglehart R.C., Ponarin E., Welzel C. Genetic factors, cultural predispositions, happiness and gender equality // Journal of Research in Gender Studies 2014 4 (1): 32-100

 

 

Регион	Популяция	Страна	Описание	Географическое описание	Широта (Latitude)	Долгота (Longitude)	N	Val-аллель  (H)         mut G	Met-аллель  (L)              mut A	Статья
Африка	Biaka	Central African Republic	3/4 "non-pygmy" African ancestry; 1/4 Mbuti ancestry	of Biaka, living in the village of Bagandu, in the southwest corner of the Central African Republic (3.42N; 18E altitude approximately 500m). (ALFRED)	3,4	18,0	70	0,943	0,057	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Африка	Mandenka	Central African Republic	Central African Republic, part of HGDP	Bangui (столица)	4,2	18,4	24	0,670	0,330	?
Африка	Mbuti	DR Congo	Nilosaharan and Niger Kordofanian speaking Mbuti pygmies	Ituri Forest, northeastern DR Congo (ALFRED)	-1,4	29,1	39	0,808	0,192	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Африка	Ewe	Ghana		Ghana, Volta Region, (центр региона, из Википедии)	7,0	0,3	32	0,700	0,300	Ameyaw MM, Syvanen AC, Ulmanen I, Ofori-Adjei D, McLeod HL. "Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population.". Hum Mutat. 16:445-6. . (2000)
Африка	Fanti	Ghana		Ghana, Central Region, (центр региона, из Википедии)	7,2	-2,2	37	0,770	0,230	Ameyaw MM, Syvanen AC, Ulmanen I, Ofori-Adjei D, McLeod HL. "Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population.". Hum Mutat. 16:445-6. . (2000)
Африка	Ga	Ghana		Accra (центр региона, из Википедии)	5,3	-0,1	46	0,800	0,200	Ameyaw MM, Syvanen AC, Ulmanen I, Ofori-Adjei D, McLeod HL. "Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population.". Hum Mutat. 16:445-6. . (2000)
Африка	Ghana	Ghana	ghanian (ewe, fanti, ga)	Accra (столица)	5,3	-0,1	190	0,740	0,260	Ameyaw MM, Syvanen AC, Ulmanen I, Ofori-Adjei D, McLeod HL. "Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population.". Hum Mutat. 16:445-6. . (2000)
Африка	kenyan (total)	Kenya		Nairoby (столица)	-1,2	36,5	102	0,680	0,320	McLeod HL, Syvänen AC, Githang'a J, Indalo A, Ismail D, Dewar K, Ulmanen I, Sludden J. Source Ethnic differences in catechol O-methyltransferase pharmacogenetics: frequency of the codon 108/158 low activity allele is lower in Kenyan than Caucasian or South-west Asian individuals.
Африка	Masai	Kenya	unrelated individuals belonging to the Masai tribe in East Africa. Groups of Masai live in Kenya and Tanzania	Ekenywa, Tanzanian-Kenyan border (ALFRED)	-2,0	36,0	20	0,675	0,325	Kenneth K. Kidd et al. "Data unpublished"
Африка	Hausa	Nigeria		Zaria, North Central Nigeria, (ALFRED)	11,0	7,4	39	0,737	0,263	Kenneth K. Kidd et al. "Data unpublished"
Африка	Ibo	Nigeria		Enugu, southeastern Nigeria, (ALFRED)	6,3	7,3	46	0,635	0,365	Kenneth K. Kidd et al. "Data unpublished"
Африка	Yoruba	Nigeria	urban health care workers	Benin City (столица)	6,3	5,6	78	0,652	0,348	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Африка	boer & afrikaners	South Africa	venous blood	Pretoria (столица)	-28,1	25,4	81	0,531	0,469	Lochner C, Kinnear CJ, Hemmings SM, Seller C, Niehaus DJ, Knowles JA, Daniels W, Moolman-Smook JC, Seedat S, Stein DJ. Hoarding in obsessive-compulsive disorder: clinical and genetic correlates. J Clin Psychiatry. 2005 Sep;66(9):1155-60.
Африка	Chagga	Tanzania	mean age of the subjects is 27.91 years. All participants were born in th Mount Kilimanjaro region and both their parents originate from the same area.	Dar-es-Salaam (столица)	-6,5	39,2	45	0,722	0,278	Kenneth K. Kidd et al. "Data unpublished"
Африка	Sandawe	Tanzania	small group of people numbering about 40,000 found in North Central Tanzania	North Central Tanzania, Kondoa (ALFRED)	-5,0	35,5	39	0,679	0,321	Kenneth K. Kidd et al. "Data unpublished"
Африка	hutu and tutsi         (refuge frome Rwanda)	Uganda		Nakivale			452			Kolassa IT, Kolassa S, Ertl V, Papassotiropoulos A, De Quervain DJ. The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism. Biol Psychiatry. 2010 Feb 15;67(4):304-8. Epub 2009 Nov 27.
Африка	algerian	Algeria	Algeria, part of HGDP	Mozabite (Википедия)	32,3	3,4	30	0,580	0,420	?
Африка	egyptian arabs	Egypt	Women, buffy coats	South Egypt, Asyut (статья)	27,1	31,1	175	0,450	0,550	Beverly J. Wolpert, Ph.D., Sania Amr, M.D., Doa’a A. Saleh, M.D., Sameera Ezzat, M.D., Iman Gouda, M.D, Iman Loay, M.D., Tamer Hifnawy, M.D., Mohamed Abdel-Hamid, Ph.D.f, Nabiel N. Mikhail, Ph.D., Min Zhan, Ph.D., Yun-Ling Zheng, M.D., Katherine Squibb, Ph.D.a, Mohamed A. Abdel-Aziz, M.D., Mohamed S. Zaghloul, M.D., Hussein Khaled, M.D., Christopher A. Loffredo, Ph.D. Associations differ by sex for catechol-O-methyltransferase genotypes and bladder cancer risk in South Egypt
Африка	egyptian arabs	Egypt	Men, buffy coats	South Egypt, Asyut (статья)	27,1	31,1	352	0,437	0,564	Beverly J. Wolpert, Ph.D., Sania Amr, M.D., Doa’a A. Saleh, M.D., Sameera Ezzat, M.D., Iman Gouda, M.D, Iman Loay, M.D., Tamer Hifnawy, M.D., Mohamed Abdel-Hamid, Ph.D.f, Nabiel N. Mikhail, Ph.D., Min Zhan, Ph.D., Yun-Ling Zheng, M.D., Katherine Squibb, Ph.D.a, Mohamed A. Abdel-Aziz, M.D., Mohamed S. Zaghloul, M.D., Hussein Khaled, M.D., Christopher A. Loffredo, Ph.D. Associations differ by sex for catechol-O-methyltransferase genotypes and bladder cancer risk in South Egypt
Африка	Ethiopian Jews	Ethiopia	part of the repository of samples on Israeli populations	Tigray&Amhara regions (Википедия)	13,3	39,3	32	0,672	0,328	?
Африка	African American	USA	throughout the USA				90	0,672	0,328	Kenneth K. Kidd et al. "Data unpublished"
Африка	black american	USA	women, cord blood	Minnesota, Minneapolis (статья)			191	0,288	0,712	Chandrasekhar Thota, PhD, Ramkumar Menon, PhD, Melissa J. Wentz, PhD, Stephen J. Fortunato, MD, Jackie Bartlett, MS, Cayce O. Drobek, BS, Sangeeta Nair, MS and Ayman Al-Hendy, MD, PhD. A Single-Nucleotide Polymorphism in the Fetal Catechol-O-methyltransferase Gene is Associated With Spontaneous Preterm Birth in African Americans.Reproductive Sciences 19(2) 135-142
Африка	black american	USA	smokers, peripheral blood	Tennessee, Mississippi, Arkansas (статья)			1366	0,520	0,480	Joke Beuten, Thomas J Payne, Jennie Z Ma and Ming D Li. Significant Association of Catechol-O-Methyltransferase (COMT) Haplotypes with Nicotine Dependence in Male and Female Smokers of Two Ethnic Populations. Neuropsychopharmacology (2006) 31, 675–684
Африка	black american	USA	peripheral blood leukocytes	North Carolina (статья)			263	0,650	0,350	Robert C. Millikan, Garry S. Pittman, Chiu Kit Tse, Eric Duell, Beth Newman, David Savitz, Patricia Moorman, Robert J.Boissy, Duglas A. Bell. Cathol-O-methyltransferase and breast cancer.Carcinogenesis. V 19. N 11. P. 1943-1947.1998
Африка	black american	USA	immortalzed cell lines, some samples frome blood and saliva	New Haven, Farmigton, Belmont, Charlestone (статья)			848	0,720	0,280	Rungnapa Ittiwut, Jennifer B. Listman, Chupong Ittiwut, Joseph F. Cubells, Roger D. Weiss, Kathleen Brady, David Oslin, Lindsay A. Farrer, Henry R. Kranzler, and Joel Gelernter. Association Between Polymorphisms in Catechol-Omethyltransferase (COMT) and Cocaine-Induced Paranoia in European-American and African-American Populations.AMERICAN JOURNAL OF MEDICAL GENETICS PART B
Азия	Ashkenazi Jews	Israel	Israel	central region of Israel (Википедия)	31,5	35,1	73	0,514	0,486	Kenneth K. Kidd et al. "Data unpublished"
Азия	Israel-Bedouin	Israel	part of HGDP	Negev region, southern Israel (ALFRED)	35,0	34,9	48	0,590	0,410	?
Азия	Israel-Druze	Israel	Moslem community	Northern Israel (ALFRED)	32,5	35,2	74	0,615	0,385	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Азия	jews (all groups)	Israel	10 ml fresh blood	Tirat Carmel (статья)	32,5	34,6	171	0,540	0,460	Michael Poyurovsky, Elena Michaelovsky, Amos Frisch, Gabriela Knoll, Ilan Amir, Boris Finkel, Feodor Buniak, Haggai Hermeshd, Ronit Weizman. COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: A case–control study. Neuroscience Letters 389 (2005) 21–24
Азия	jews (all groups)	Israel	frozen blood	Beersheva (статья)	31,2	34,5	415	0,547	0,453	Moshe Kotler, Peretz Barak, Hagit Cohen, Ilya E. Averbuch, Alexander Grinshpoon, Inga Gritsenko, Lubov Nemanov, Richard P. Ebstein Homicidal Behavior in Schizophrenia Associated цith a Genetic Polymorphism Determining Low Catechol O-Methyltransferase (COMT) Activity. American Journal of Medical Genetics (Neuropsychiatric Genetics) 88: 628–633 (1999)
Азия	jews (ashkenazi)	Israel	frozen blood, *	Beersheva (статья)	31,2	34,5	257	0,547	0,453	Moshe Kotler, Peretz Barak, Hagit Cohen, Ilya E. Averbuch, Alexander Grinshpoon, Inga Gritsenko, Lubov Nemanov, Richard P. Ebstein Homicidal Behavior in Schizophrenia Associated цith a Genetic Polymorphism Determining Low Catechol O-Methyltransferase (COMT) Activity. American Journal of Medical Genetics (Neuropsychiatric Genetics) 88:628–633 (1999)
Азия	Palestinian	Israel	part of HGDP	central region of Israel (ALFRED)	31,5	35,1	51	0,430	0,570	?
Азия	palestinian arabs	Israel	?	Northern Part, Nazareth (статья)	32,4	35,2	77	0,435	0,565	I. Kremer, M. Pinto, I. Murad, M. Muhaheed, I. Bannoura, D.J. Muller, T.G. Schulze, A. Reshef, M. Blanaru, S. Gathas, R. Goichman, M. Rietschel, M. Dobrusin, R. Bachner-Melman, L. Nemanov, R.H. Belmaker, W. Maier, and R.P. Ebstein. Family-Based and Case–Control Study of Catechol-O Methyltransferase in Schizophrenia Among Palestinian Arabs
Азия	Samaritans	Israel		Holon (Википедия)	32,0	34,5	40	0,550	0,450	Kenneth K. Kidd et al. "Data unpublished"
Азия	Yemenite Jews	Yemen	unrelated individuals born in Yemen	Yemen (столица)	15,2	14,1	43	0,616	0,384	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Азия
Европа	hungarian (magyar)	Hungary	Buccal samples	Budapest (столица)	47,3	19,1	127	0,504	0,496	Anna Szekely, Reka Kovacs-Nagy, Éva I. Bányai,Anna C. Gősi-Greguss, Katalin Varga, Zsuzsa Halmai, Zsolt Ronai & Maria Sasvari-Szekely Association Between Hypnotizability and the Catechol- O-Methyltransferase (COMT) Polymorphism. Intl. Journal of Clinical and Experimental Hypnosis, 58(3): 301–315, 2010
Европа	hungarian (magyar)	Hungary	?	Budapest (столица)	47,3	19,1	284	0,453	0,547	Eva Kereszturi, Zsanett Tarnok, Emese Bognar, Krisztina Lakatos, Luca Farkas, Julia Gadoros, Maria Sasvari-Szekely, and Zsofia Nemoda Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated With Methylphenidate Response in ADHD Children. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 147B:1431–1435 (2008)
Европа	hungarian (magyar)	Hungary	buccal epithelial cells	Budapest (столица)	47,3	19,1	124	0,500	0,500	Zsolt Demetrovics, Gabor Varga, Anna Szekely, Andrea Vereczkei, Jozsef Csorbad, Hedvig Balazsa, Katalin Hoffmana, Maria Sasvari-Szekelyc, Csaba Bartac, Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val158Met polymorphism Comprehensive Psychiatry 51 (2010) 510–515
Европа	hungarian	Hungary	unrelated Hungarians	Budapest (ALFRED)	47,3	19,0	92	0,437	0,563	Kenneth K. Kidd et al. "Data unpublished"
Европа	hungarian	Hungary	unrelated Hungarian subjects with no psychiatric history	Budapest (столица)	47,3	19,0	178	0,497	0,503	Nemoda Z, Lyons-Ruth K, Szekely A, Bertha E, Faludi G, Sasvari-Szekely M. "Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients". Behav Brain Funct 6:(2010)
Европа	poles	Poland	women, blood	Szczecin (статья)	53,7	14,3	108	0,439	0,562	Elżbieta Mikołajczyk, Anna Grzywacz, Jerzy Samochowiec. The association of catechol-O-methyltransferase genotype with the phenotype of women with eating disorders. Brain Research. 1 3 0 7 ( 2 0 1 0 ) 1 4 2 – 1 4 8
Европа	poles	Poland	uncoagulated venous blood samples	Stanomino (статья)	53,6	15,5	150	0,510	0,490	Jerzy Samochowiec, Jolanta Kucharska-Mazur, Anna Grzywacz, Justyna Pelka-Wysiecka, Monika Mak, Agnieszka Samochowiec, Przemyslaw Bienkowski. Genetics of Lesch's typology of alcoholism. Progress in Neuro-Psychopharmacology & Biological Psychiatry 32 (2008) 423–427
Европа	poles	Poland	leucocytes contained in venous blood	Szczecin (статья)	53,7	14,3	152	0,402	0,599	Monika Białecka Marek Droz´dzik Krystyna Honczarenko Barbara Gawron´ ska-Szklar, Jan Stankiewicz Ewa D browska Maciej  Kubisiak Gabriela Kłodowska-Duda Grzegorz Opala. Catechol-O-Methyltransferase and Monoamine Oxidase B Genes and Susceptibility to Sporadic Parkinson’s Disease in a Polish Population. Eur Neurol 2005;53:68–73
Европа	poles	Poland	woman, Peripheral blood	Szczecin (статья)	53,7	14,3	116	0,479	0,522	Elżbieta Mikołajczyk Małgorzata Śmiarowska Anna Grzywacz Jerzy Samochowiec. Association of Eating Disorders with Catechol- O Methyltransferase Gene Functional Polymorphism. Neuropsychobiology 2006;54:82–86
Европа	poles	Poland	women, buffy coats	Lodz + Warsaw (статья)	52,1	21,0	2296	0,529	0,472	Mia M. Gaudet, Stephen Chanock, Jolanta Lissowska, et al.  Catechol-O- Comprehensive Assessment of Genetic Variation of Methyltransferase and Breast Cancer Risk. Cancer Res 2006;66:9781-9785
Европа	adygei	Russia		Krasnodar (ALFRED)	45,0	38,6	54	0,657	0,343	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Европа	chuvash	Russia		southern Ural Mountains region of Russia (ALFRED)	55,3	47,1	42	0,452	0,548	Kenneth K. Kidd et al. "Data unpublished"
Европа	komi-zyrian	Russia		in the village of Kazak on the Kazak River. The Kazak River is the right tributary of the Ob River (near the Ural Mountains), (ALFRED) Vorkuta (Википедия)	67,3	60,0	47	0,617	0,383	Kenneth K. Kidd et al. "Data unpublished"
Европа	russian	Russia		Vologda (ALFRED)	59,1	39,5	48	0,490	0,510	?
Европа	russian	Russia	small, relatively isolated population, population has ~900 members	Arkhangel'sk (ALFRED)	64,3	40,3	33	0,424	0,576	?
Европа	russian	Russia	male, blood from arm veins	Arhangel'sk (статья)	64,3	40,32	60	0,490	0,510	ELENA L. GRIGORENKO, COLIN G. DEYOUNG, MARYA GETCHELL, GERALD J. HAEFFEL, BRITT A.F. KLINTEBERG, ROMAN A. KOPOSOV, LARS ORELAND, ANDREW J. PAKSTIS, VLADISLAV V. RUCHKIN AND CAROLYN M. YRIGOLLEN Exploring interactive effects of genes and environments in etiology of individual differences in reading comprehension. Development and Psychopathology 19 (2007), 1089–1103
Европа	russian	Russia	men, venous blood	Moscow (статья)	55,5	37,37	44	0,523	0,477	Olga V. Sysoeva, Alexander G. Tonevitsky, Jirˇı´ Wackermann. Genetic Determinants of Time Perception Mediated by the Serotonergic System
Европа	russian	Russia	white cells of venous blood	Moscow (статья)	55,5	37,37	130	0,519	0,481	VERA GOLIMBET, INGA GRITSENKO, MARGARITA ALFIMOVA, IRINA LEBEDEVA, TATYANA LEZHEIKO, LILIA ABRAMOVA, VASILY KALEDA& RICHARD EBSTEIN. Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocognitive tests in patients with schizophrenia and their relatives. The World Journal of Biological Psychiatry, 2006; 7(4): 238 245
Европа	russian	Russia		Bryansk+Tula (статья)
Европа	slovaks	Slovakia
Европа	danes	Denmark	unrelated individuals from large pedigrees	Copenhagen (столица)	55,4	12,4	51	0,392	0,608	?
Европа	danes	Denmark	blood sample buffy coats	Copenhagen (статья)	55,4	12,4	265	0,324	0,676	Sofia I. I. Kring, Thomas Werge, Claus Holst, Søren Toubro, Arne Astrup, Torben Hansen, Oluf Pedersen, Thorkild I. A. Sørensen. Polymorphisms of Serotonin Receptor 2A and 2C Genes and COMT in Relation to Obesity and Type 2 Diabetes
Европа	estonian	Estonia	Eighty samples (40 males and 40 females) were selected randomly, according to the place of birth, from each of 13 Estonian counties	Tallin (столица)	59,3	24,5	1000	0,428	0,572	?
Европа	estonian	Estonia					110			Maron E, Tõru I, Tasa G, Must A, Toover E, Lang A, Vasar V, Shlik J. Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers.Neurosci Lett. 2008 Dec 3;446(2-3):88-92.
Европа	finish	Finland	several different parts of Finland	Helsinki (столица)	60,1	24,6	36	0,471	0,529	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Европа	Finns	Finland	blood	Jyväskylä (статья)	62,1	25, 44	247	0,414	0,586	ANNA-LENA ERIKSSON, MIIA SUURINIEMI, ANITTA MAHONEN, SULIN CHENG, AND CLAES OHLSSON. The COMT val158met Polymorphism Is Associated with Early Pubertal Development, Height and Cortical Bone Mass in Girls. PEDIATRIC RESEARCH Vol. 58, No. 1, 2005
Европа	finns	Finland	(hight coronary desease region), venous blood samples	Kuopio (статья)	62,5	27,4	896	0,461	0,539	Jussi Kauhanen, Tero Hallikainen, Tomi-Pekka Tuomainen, Markku Koulu, Matti K. Karvonen, Jukka T Salonen, and Jari Tiihonen. Association Between the Functional Polymorphism of Catechol-0-Methyltransferase Gene and Alcohol Consumption Among Social Drinkers. Alcohol Clin Exp Res, Vol24, No 2, 2000: pp 135-1 39
Европа	finns	Finland	musicians, Peripheral venous blood	Helsinki (статья)	60,1	24,6	343	0,423	0,577	Liisa T. Ukkola, Pa¨ ivi Onkamo, Pirre Raijas, Kai Karma, Irma Jarvela Musical Aptitude Is Associated with AVPR1A-Haplotypes
Европа	finns	Finland	twins, blood samples	Helsinki (статья)	60,1	24,6	424	0,422	0,578	Paula H. A. Ronkainen, Eija Po¨ lla¨nen, Timo To¨rma¨kangas, Kristina Tiainen, Markku Koskenvuo, Jaakko Kaprio, Taina Rantanen, Sarianna Sipila, Vuokko Kovanen. Functional COMT Val158Met Polymorphism, Risk of Acute Coronary Events and Serum Homocysteine: The Kuopio Ischaemic Heart Disease Risk Factor Study
Европа	finns	Finland	(hight coronary desease region), venous blood samples	Kuopio (статья)	62,5	27,4	792	0,472	0,529	Sari Voutilainen, Tomi-Pekka Tuomainen, Maarit Korhonen, Jaakko Mursu, Jyrki K. Virtanen, Pertti Happonen, Georg Alfthan, Iris Erlund, Kari E. North, M. J. Mosher, Jussi Kauhanen, Jari Tiihonen, George A. Kaplan, Jukka T. Salonen Functional COMT Val158Met Polymorphism, Risk of Acute Coronary Events and Serum Homocysteine: The Kuopio Ischaemic Heart Disease Risk Factor Study
Европа	finns	Finland	?	Helsinki (статья)	60,1	24,6	687	0,500	0,500	Ummiye V Onay, Kirsimari Aaltonen, Laurent Briollais, Julia A Knight, Noel Pabalan, Outi Kilpivaara, Irene L Andrulis, Carl Blomqvist, Heli Nevanlinna and Hilmi Ozcelik. Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk. BMC Cancer 2008,
Европа	icelanders	Iceland	blood	Reykjavik (столица)	64,1	-21,5	95	0,415	0,585	Haraldur Magnus Haraldsson, Ulrich Ettinger, Brynja B. Magnusdottir, Thordur Sigmundsson, Engilbert Sigurdsson, Andres Ingason, and Hannes Petursson Catechol-O-Methyltransferase Val158Met Polymorphism and Antisaccade Eye Movements in Schizophrenia. Schizophrenia Bulletin vol. 36 no. 1 pp. 157–164, 2010
Европа	norvegian	Norway	Blood sampling	Nord-Trøndelag, Steinkjer (статья)	64,0	11,3	2623	0,435	0,565	Dr Knut Hagen, Lars Jacob Stovner, Frank Skorpen, Elin Pettersen and John-Anker Zwart COMT genotypes and use of antipsychotic medication: linking population-based prescription database to the HUNT study. pharmacoepidemiology and drug safety 2008; 17: 372–377
Европа	norvegian	Norway	Saliva or venous blood	Oslo (столица)	59,5	10,5	383	0,440	0,560	H. Halleland, A.J. Lundervold, A. Halmøy, J. Haavik, and S. Johansson. Association Between Catechol O-methyltransferase (COMT) Haplotypes and Severity of Hyperactivity Symptoms in Adults. Am J Med Genet Part B 150B:403–410.
Европа	norvegian	Norway	whole blood or blood clots	Nord-Trøndelag, Steinkjer (статья)	64,0	11,3	1492	0,418	0,582	Knut Hagen, Elin Pettersen, Lars Jacob Stovner, Frank Skorpen and John-Anker Zwart No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study. BMC Musculoskeletal Disorders 2006, 7:40
Европа	norvegian	Norway	whole blood or blood clots	Nord-Trøndelag, Steinkjer (статья)	64,0	11,3	1475	0,426	0,574	Knut Hagen, Elin Pettersen, Lars Jacob Stovner, Frank Skorpen and John-Anker Zwart No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study. BMC Musculoskeletal Disorders 2006, 7:40
Европа	norvegian	Norway	peripheral blood leukocytes	Nord-Trøndelag, Steinkjer (статья)	64,0	11,3	2979	0,423	0,577	Knut Hagen, Lars J Stovner, Frank Skorpen, Elin Pettersen and John- Anker Zwart The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study. BMC Medical Genetics 2007, 8:34
Европа	norvegian	Norway	blood	Nord-Trøndelag, Steinkjer (статья)	64,0	11,3	2029	0,440	0,560	L.T. Roten, M.H. Fenstad, S. Forsmo, M.P. Johnson, E.K. Moses, R. Austgulen, and F. Skorpen. A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2). Molecular Human Reproduction, Vol.17, No.7 pp. 439–446, 2011
Европа	norvegian	Norway	men, peripheral blood leukocytes	Oslo (статья)	59,5	10,5	1709	0,419	0,582	Petter M Bækken, Frank Skorpen, Eystein Stordal, John-Anker Zwart and Knut HagenDepression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT) BMC Psychiatry 2008, 8:48
Европа	norvegian	Norway	women, peripheral blood leukocytes	Oslo (статья)	59,5	10,5	1796	0,447	0,553	Petter M Bækken, Frank Skorpen, Eystein Stordal, John-Anker Zwart and Knut HagenDepression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT) BMC Psychiatry 2008, 8:48
Европа	norvegian	Norway	?	Oslo (статья)	59,5	10,5	257	0,634	0,366	Shanbeh Zienolddiny, Daniele Campa, Helge Lind, David Ryberg, Vidar Skaug, Lodve B.Stangeland, Federico Canzian4 and Aage Haugen. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers.Carcinogenesis vol.29 no.6 pp.1164–1169, 2008
Европа	sweds	Sweden	Blood samples	Goteborg (статья)	57,4	11,83	348	0,415	0,585	Anna-Lena Erikssona, Stanko Skrtica, Anders Niklasona, Lillemor Mattsson Hult enc, Olov Wiklundc, Thomas Hednera, Claes Ohlssona. Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population
Европа	sweds	Sweden	female, blood	Kalmar (статья)	56,4	16,22	117	0,381	0,619	M Bergman-Jungeström and S Wingren. polymorphism and breast cancer risk in young women. British Journal of Cancer (2001) 85(6), 859–862
Европа	sweds	Sweden	whole blood	Stockholm (столица)	59,2	18,47	458	0,440	0,560	Mattias Lorentzon, Anna-Lena Eriksson, Dan Mellstrom, and Claes Ohlsson. The COMT val158met Polymorphism Is Associated With Peak BMD in Men. JOURNAL OF BONE AND MINERAL RESEARCH Volume 19, Number 12, 2004
Европа	sweds	Sweden	Caucasian, general population (51% women)	Nothern sweden, Umeå (статья)	63,5	20,15	867	0,445	0,555	Karling P, Danielsson Å, Wikgren M, Söderström I, Del-Favero J, Adolfsson R, Norrback KF. The relationship between the val158met catechol-O-methyltransferase (COMT) polymorphism and irritable bowel syndrome. PLoS One. 2011 Mar 18;6(3):e18035.
Европа	sweds	Sweden	female, Whole blood	Stockholm (статья)	59,2	18,47	1252	0,436	0,564	Sara Wedren, Tove Rylander Rudqvist, Fredrik Granath, Elisabete Weiderpass, Magnus Ingelman-Sundberg, Ingemar Persson and Cecilia Magnusson Catechol-O-methyltransferase gene polymorphism and post-menopausal breast cancer risk. Carcinogenesis vol.24 no.4 pp.681±687, 2003
Европа	swiss	Switzerland	blood	Geneva (статья)	46,1	6,1	99	0,525	0,475	Jules Desmeules, Valerie Piguet, Marie Besson, Jocelyne Chabert, Elisabetta Rapiti, Michela Rebsamen, Michel F. Rossier, Franc¸ois Curtin, Pierre Dayer, and Christine Cedraschi. Psychological Distress in Fibromyalgia Patients: A Role for Catechol-O-Methyl-Transferase Val158Met Polymorphism. Health Psychology. 2012, Vol. 31, No. 2, 242–249
Европа	swiss	Switzerland	women, Blood	Geneva (статья)	46,1	6,1	185	0,473	0,527	Patrick Baud, Philippe Courtet, Nader Perroud, Fabrice Jollant, Catherine Buresi, and Alain Malafosse. Catechol-O-Methyltransferase Polymorphism (COMT) in Suicide Attempters: A Possible Gender Effect on Anger Traits. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 144B:1042–1047 (2007)
Европа	austrians	Austria		Vienna (статья)	48,1	16, 22				Manuel Fernández Martínez, Xabier Elcoroaristizabal Martín, Luís Galdos Alcelay, Jessica Castro Flores, Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Ángeles Gómez Beldarraín,Josefa Moraza López, María Carmen Gonzalez-Fernández, Ana Molano Salazar, Rocio Bereincua Gandarias, Sandra Inglés Borda, Nuria Ortiz Marqués, Miryam Barandiarán Amillano, María Carrasco Zabaleta and Marian M de Pancorbo. The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers. BMC Neuroscience 2009, 10:125
Европа	belgians (flemings)	Belgium	?	Brussels (столица)	50,5	4,2	621	0,510	0,491	Marieke Wichers, Mari Aguilera, Gunter Kenis, Lydia Krabbendam, Inez Myin-Germeys, Nele Jacobs, Frenk Peeters, Catherine Derom, Robert Vlietinck, Ron Mengelers, Philippe Delespaul and Jim van Os. The Catechol-O-Methyl Transferase Val158Met Polymorphism and Experience of Reward in the Flow of Daily Life. Neuropsychopharmacology (2008) 33, 3030–3036
Европа	basque	France	from France	French part of Basque Country, Bayonne (Википедия)	43,3	-1,3	24	0,420	0,580	?
Европа	french	France	various regions of France, part of HGDP	Paris (столица)	48,5	2,2	28	0,530	0,470	?
Европа	french	France	whole blood	Clermont-Ferrand (статья)	45,5	3,1	1000	0,477	0,523	Laetitia Delort, Samir Satih, Fabrice Kwiatkowski, Yves-Jean Bignon & Dominique J Bernard-Gallon. Evaluation of Breast Cancer Risk in a Multigenic Model Including Low Penetrance Genes Involved in Xenobiotic and Estrogen Metabolisms. Nutrition and Cancer, 62(2), 243–251
Европа	french	France	whole blood sample	Nancy, Brest, Paris (статья)	48,5	2,2	882	0,501	0,499	Olivier Cussenot, Abdel Rhamene Azzouzi, Nathalie Nicolaiew, Gaelle Fromont, Philippe Mangin, Luc Cormier, Georges Fournier, Antoine Valeri, Stephane Larre, Frederic Thibault, Jean-Pierre Giordanella, Michel Pouchard, Yan Zheng, Freddie C. Hamdy, Angela Cox, and Geraldine Cancel-Tassin. Genes Related to Estrogen and Prostate Cancer
Европа	german	Germany	female postmenopausal	Heidelberg (статья)	49,2	8,4	774	0,510	0,490	Rudolph A, Sainz J, Hein R, Hoffmeister M, Frank B, Försti A, Brenner H, Hemminki K, Chang-Claude J. Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes. Endocr Relat Cancer. 2011 Jun 8;18(3):371-84. Print 2011 Jun.
Европа	germanese	Germany	?	Muenster (статья)	51,6	7,4	557	0,448	0,552	Bernhard T Baune, Christa Hohoff, Klaus Berger, Anna Neumann, Sunke Mortensen, Tilmann Roehrs, Ju¨rgen Deckert, Volker Arolt1 and Katharina Domschke1. Association of the COMT val158met Variant with Antidepressant Treatment Response in Major Depression. Neuropsychopharmacology (2008) 33, 924–932
Европа	germanese	Germany	cheek swabs or whole blood	Berlin (столица)	52,3	13,2	192	0,443	0,557	Manuel Fernández Martínez, Xabier Elcoroaristizabal Martín, Luís Galdos Alcelay, Jessica Castro Flores, Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Ángeles Gómez Beldarraín,Josefa Moraza López, María Carmen Gonzalez-Fernández, Ana Molano Salazar, Rocio Bereincua Gandarias, Sandra Inglés Borda, Nuria Ortiz Marqués, Miryam Barandiarán Amillano, María Carrasco Zabaleta and Marian M de Pancorbo. The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers. BMC Neuroscience 2009, 10:125
Европа	germanese	Germany	buccal cells	Berlin (статья)	52,3	13,2	295	0,493	0,507	Martin Reuter, Anja Schmitz, Philip Corr and Juergen Hennig. Molecular genetics support Gray’s personality theory: the interaction of COMT and DRD2 polymorphisms predicts the behavioural approach system. International Journal of Neuropsychopharmacology (2005), 8, 1–12. Copyright
Европа	germanese	Germany	?	Hamburg (статья)	53,3	10,0	5.481	0,470	0,530	The MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. Breast Cancer Res Treat (2010) 119:463–474
Европа	germanese	Germany	?	Berlin (статья)	52,3	13,2	282	0,446	0,555	Tomislav Majic, Johannes Rentzsch, Yehonala Gudlowski, Stefan Ehrlich, Georg Juckel, Thomas Sander, Undine E. Lang, Georg Winterer, Jürgen Gallinat. COMT Val108/158Met genotype modulates human sensory gating. NeuroImage 55 (2011) 818–824
Европа	germanese	Germany	?	Berlin (статья)	52,3	13,2	432	0,453	0,547	Undine E Lang, Malck Bajbouj, Thomas Sander and Juergen Gallinat. Catechol-O-Methyltransferase Val158Met Gender-Dependent Association of the Functional Catechol-O-Methyltransferase Val158Met Genotype with Sensation Seeking Personality Trait. Neuropsychopharmacology (2007) 32, 1950–1955
Европа	irish	Ireland		northern and central, Dublin (статья)	53,2	-6,0	115	0,500	0,500	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Европа	irishman + englishman	Ireland	blood	Dublin (столица)	53,2	-6,2	710	0,485	0,515	Hywel J. Williams, B.Sc. Beate Glaser, Ph.D.Nigel M. Williams, B.Sc. Nadine Norton, Ph.D.Stanley Zammit, M.D., Ph.D. Stuart Macgregor, Ph.D. George K. Kirov, M.D., Ph.D. Michael J. Owen, M.D., Ph.D. Michael C. O’Donovan, M.D., Ph.D. No Association Between Schizophrenia and Polymorphisms in COMT in Two Large Samples. (Am J Psychiatry 2005; 162:1736–1738)
Европа	dutch (netherlanders)	Netherlands	venous blood samples	Amsterdam (столица)	52,2	4,5	445	0,410	0,591	A.A.J. van Esch, E. de Vries, R.H.M. te Morsche, M.G.H. van Oijen, J.B.M.J. Jansen, J.P.H. Drenth. Catechol-O-methyltransferase (COMT) gene variants and pain in chronic pancreatitis. The Nitherlands Journal of Medicine.   j u l y/ A u g u s t  2 0 1 1 , v o l . 6 9 , n o 7 / 8
Европа	dutch (netherlanders)	Netherlands	blood, buccal swabs and, in a few cases, saliva.	Utrecht, Amsterdam, Groningen (статья)	52,2	4,5	462	0,489	0,511	Hilga Katerberg, Danielle C. Cath, Damiaan A.J. P. Denys, Peter Heutink, Annemiek Polman, Filip C. W. van Nieuwerburgh, Dieter L.D. Deforce, Zolt an Bochdanovits, Anton J. L. M. van Balkom, and Johan A. den Boer. The Role of the COMT Val158Met Polymorphism in the Phenotypic Expression of Obsessive-Compulsive Disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B
Европа	dutch (netherlanders)	Netherlands	both sex blood	Ommoord district of Rotterdam (статья)	51,6	4,3	6060	0,350	0,650	Lisette Stolk, Joyce B. J. van Meurs, Mila Jhamai, Pascal P. Arp, Johannes P. T. van Leeuwen, Albert Hofman, Frank H. de Jong, Huibert A. P. Pols, and Andre´ G. Uitterlinden. The Catechol-O-Methyltransferase Met158 Low-Activity Allele and Association with Nonvertebral Fracture Risk in Elderly Men. The Journal of Clinical Endocrinology & Metabolism 92(8):3206–3212
Европа	dutch (netherlanders)	Netherlands	women, blood	Ommoord district of Rotterdam (статья)	51,6	4,3	3554	0,455	0,545	Lisette Stolk, Joyce B. J. van Meurs, Mila Jhamai, Pascal P. Arp, Johannes P. T. van Leeuwen, Albert Hofman, Frank H. de Jong, Huibert A. P. Pols, and Andre´ G. Uitterlinden. The Catechol-O-Methyltransferase Met158 Low-Activity Allele and Association with Nonvertebral Fracture Risk in Elderly Men. The Journal of Clinical Endocrinology & Metabolism 92(8):3206–3212
Европа	dutch (netherlanders)	Netherlands	men, blood	Ommoord district of Rotterdam (статья)	51,6	4,3	2515	0,455	0,545	Lisette Stolk, Joyce B. J. van Meurs, Mila Jhamai, Pascal P. Arp, Johannes P. T. van Leeuwen, Albert Hofman, Frank H. de Jong, Huibert A. P. Pols, and Andre´ G. Uitterlinden. The Catechol-O-Methyltransferase Met158 Low-Activity Allele and Association with Nonvertebral Fracture Risk in Elderly Men. The Journal of Clinical Endocrinology & Metabolism 92(8):3206–3212
Европа	englishmen	U.K.(Britain)	blood and mouthwash	southwest of England,           Bristol (статья)	51,3	-2,4	8.707	0,491	0,509	Jennifer H. Barnett, Ph.D. Jon Heron, Ph.D. Susan M. Ring, Ph.D. Jean Golding, Ph.D., D.Sc. David Goldman, M.D. Ke Xu, Ph.D. Peter B. Jones, Ph.D. Gender-Specific Effects of the Catechol-O-Methyltransferase Val108/158Met Polymorphism on Cognitive Function in Children. Am J Psychiatry 2007; 164:142–149).
Европа	scotts	U.K.(Britain)		Edinburgh (статья)	55,6	-3,1	1091			L. M. Houlihan, S. E. Harris†, M. Luciano, A. J. Gow, J. M. Starr, P. M. Visscher and I. J. Deary, Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936. Genes, Brain and Behavior (2009) 8: 238–247
Европа	welsh	U.K.(Britain)	women, leukocytes	Cardiff (статья)	51,3	3,1	192	0,401	0,599	Nadine Norton, George Kirov, Stan Zammit, Gaynor Jones, Susan Jones, Richard Owen, Michael Krawczak, Nigel M. Williams, Michael C. O’Donovan, and Michael J. Owen. Schizophrenia and Functional Polymorphisms in the MAOA and COMT Genes: No Evidence for Association or Epistasis. American Journal of Medical Genetics (Neuropsychiatric Genetics) 114:491–496 (2002)
Европа	welsh	U.K.(Britain)	men, leukocytes	Cardiff (статья)	51,3	3,1	476	0,481	0,519	Nadine Norton, George Kirov, Stan Zammit, Gaynor Jones, Susan Jones, Richard Owen, Michael Krawczak, Nigel M. Williams, Michael C. O’Donovan, and Michael J. Owen. Schizophrenia and Functional Polymorphisms in the MAOA and COMT Genes: No Evidence for Association or Epistasis. American Journal of Medical Genetics (Neuropsychiatric Genetics) 114:491–496 (2002)
Европа	welsh+english	U.K.(Britain)	members of the Environmental risk, buccal swabs	Cardiff (статья)	51,3	3,1	2.232	0,495	0,505	Avshalom Caspi, PhD; Kate Langley, PhD; Barry Milne, MSc; Terrie E. Moffitt, PhD; Michael O’Donovan, MD; Michael J. Owen, MD; Monica Polo Tomas, MSc; Richie Poulton, PhD; Michael Rutter, MD; Alan Taylor, MSc; Benjamin Williams, BSc; Anita Thapar, MDA Replicated Molecular Genetic Basis for Subtyping Antisocial Behavior in Children With Attention-Deficit/Hyperactivity Disorder. Arch Gen Psychiatry. 2008;65(2):203-210
Европа	welsh+english	U.K.(Britain)	?	South Wales, Bristol, Greater Manchester, London (статья)	51,3	0,1	246	0,520	0,480	D. Turic, H. Williams, K. Langley, M. Owen, A. Thapar,* and M.C. O’Donovan. A Family Based Study of Catechol-O-Methyltransferase(COMT) and Attention Deficit Hyperactivity Disorder (ADHD) American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 133B:64–67 (2005)
Европа	croats	Bosnia
Европа	croats	Croatia	men	Zagreb (статья)	45,5	15,6	578	0,519	0,481	Gordana Nedica, Matea Nikolaca, Fran Boroveckib, Sanja Hajnsek, Dorotea Muck-Selera, Nela Pivaca, Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects Neuroscience Letters 473 (2010) 216–219
Европа	croats	Croatia	women	Zagreb (статья)	45,5	15,6	79	0,544	0,457	Gordana Nedica, Matea Nikolaca, Fran Boroveckib, Sanja Hajnsek, Dorotea Muck-Selera, Nela Pivaca, Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects Neuroscience Letters 473 (2010) 216–219
Европа	croats	Croatia	whole blood	Zagreb (статья)	45,5	15,6	131			Prodipto Pal, Mate Mihanović, Sven Molnar, Huifeng Xi, Guangyun Sun, Saurav Guha, Nina Jeran, Andrea Tomljenović, Ana Malnar, Saša Missoni, Ranjan Deka, Pavao Rudan. Association of Tagging Single Nucleotide Polymorphisms on 8 Candidate Genes in Dopaminergic Pathway with Schizophrenia in Croatian Population. Croat Med J. 2009; 50: 361-9
Европа	greeks	Greece	men	Athens (столица)	37,6	23,4	379	0,464	0,536	D Avramopoulos, NC Stefanis, I Hantoumi, N Smyrnis, I Evdokimidis and CN Stefanis Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele. Molecular Psychiatry (2002) 7, 706–711
Европа	greeks	Greece	men	Athens (статья)	37,6	23,4	527	0,436	0,564	Nicholas C. Stefanis, M.D. Jim van Os, M.D., Ph.D. Dimitrios Avramopoulos, M.D., Ph.D. Nikolaos Smyrnis, M.D. Ioannis Evdokimidis, M.D. Costas N. Stefanis, M.D. Effect of COMT Val158Met Polymorphism on the Continuous Performance Test, Identical Pairs Version: Tuning Rather Than Improving Performance. Am J Psychiatry 2005; 162:1752–1754.
Европа	italian	Italy		Sardinia, Cagliari (ALFRED)	39,1	9,0	28	0,640	0,360	?
Европа	italians	Italy	peripheral blood	Rome (статья)	41,5	12,3	149	0,524	0,476	A. CERASA,A. CHERUBINI, A. QUATTRONE, M.C. GIOIA, P. TARANTINO G. ANNESI F. ASSOGNA C. CALTAGIRONE AND G. SPALLETTA. MET158 VARIANT OF THE CATECHOL-O-METHYLTRANSFERASE GENOTYPE IS ASSOCIATED WITH THICKER CORTEX IN ADULT BRAIN. Neuroscience 167 (2010) 809–814
Европа	italians	Italy	blood leukocytes	Pisa (статья)	43,4	10,2	127	0,610	0,390	Alessandro Rotondo, M.D. Chiara Mazzanti, Ph.D. Liliana Dell’Osso, M.D. Paola Rucci, Dr.Stat.Patrick Sullivan, M.D. Siham Bouanani, M.D. Chiara Gonnelli, M.D. David Goldman, M.D. Giovanni B. Cassano, M.D., F.R.C.Psych.Catechol O-Methyltransferase, Serotonin Transporter, and Tryptophan Hydroxylase Gene Polymorphisms in Bipolar Disorder Patients With and Without Comorbid Panic Disorder. Am J Psychiatry 2002; 159:23–29
Европа	italians	Italy	?	Brescia (статья)	45,3	10,1	208	0,530	0,470	Barbara Borronia, Chiara Agosti, Silvana Archetti, Chiara Costanzi, Silvia Bonomi, Diego Ghianda, Gian Luigi Lenzi, Luigi Caimi, Monica Di Luca, Alessandro Padovani. Catechol-O-methyltransferase gene polymorphism is associated with risk of psychosis in Alzheimer Disease. Neuroscience Letters 370 (2004) 127–129
Европа	italians	Italy	cheek swabs or whole blood	Florence (статья)	43,5	11,2	166	0,530	0,470	M. Gabrovsek, M. Brecelj-Anderluh, L. Bellodi, E. Cellini, D. Di Bella, X. Estivill, F. Fernandez-Aranda, B. Freeman, F. Geller, M. Gratacos, R. Haigh, J. Hebebrand, A. Hinney, J. Holliday, X. Hu, A. Karwautz, B. Nacmias, M. Ribases, H. Remschmidt, R. Komel, S. Sorbi, M. Tomori, J. Treasure, G. Wagner, J. Zhao, and D.A. Collier Combined Family Trio and Case-Control Analysis of the COMT Val158Met Polymorphism in European Patients With Anorexia Nervosa. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 124B:68–72 (2004)
Европа	italians	Italy	cheek swabs or whole blood	Milan (статья)	45,3	9,1	292	0,510	0,490	M. Gabrovsek, M. Brecelj-Anderluh, L. Bellodi, E. Cellini, D. Di Bella, X. Estivill, F. Fernandez-Aranda, B. Freeman, F. Geller, M. Gratacos, R. Haigh, J. Hebebrand, A. Hinney, J. Holliday, X. Hu, A. Karwautz, B. Nacmias, M. Ribases, H. Remschmidt, R. Komel, S. Sorbi, M. Tomori, J. Treasure, G. Wagner, J. Zhao, and D.A. Collier Combined Family Trio and Case-Control Analysis of the COMT Val158Met Polymorphism in European Patients With Anorexia Nervosa. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 124B:68–72 (2004)
Европа	italians	Italy	whole blood	Brescia (статья)	45,3	10,1	214	0,530	0,470	Rayjean J.Hung, Paolo Boffetta, Paul Brennan, Christian Malaveille, Umberto Gelatti, Donatella Placidi, Angela Carta, Agn es Hautefeuille and Stefano Porru. Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk. Carcinogenesis vol.25 no.6 pp.973--978, 2004
Европа	portugueses*	Portugal		Lisbon (статья)	38,4	9,08	457			SUSANA N. SILVA, MARISA N. CABRAL, GUILHERME BEZERRA DE CASTRO, MARCELO PIRES, ANA PAULA AZEVEDO, ISABEL MANITA, JULIETA ESPERANÇA PINA, JOSÉ RUEFF and JORGE GASPAR Breast cancer risk and polymorphisms in genes involved in metabolism of estrogens (CYP17, HSD17ß1, COMT and MnSOD): Possible protective role of MnSOD gene polymorphism Val/Ala and Ala/Ala in women that never breast fed. ONCOLOGY REPORTS 16: 781-788, 2006
Европа	slovenes	Slovenia	women, whole blood	Ljublana (статья)	46,0	14,3	270	0,500	0,500	Jasmina-Ziva Cerne, Maja Pohar-Perme, Srdjan Novakovic, Snjezana Frkovic-Grazio, Vida Stegel, Ksenija Gersak Combined effect of CYP1B1, COMT, GSTP1, and MnSOD genotypes and risk of postmenopausal breast cancer. J Gynecol Oncol Vol. 22, No. 2:110-119
Европа	slovenes	Slovenia	men, Venous blood	Ljublana (статья)	46,0	14,3	132	0,432	0,568	N. Pivac, P. Pregel, M. Nikolac, T. Zupanc, G. Nedic, D. Muck Seler and A. Videtic Paska, The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide. Genes, Brain and Behavior (2011) 10: 565–569
Европа	slovenes	Slovenia	women, Venous blood	Ljublana (статья)	46,0	14,3	66	0,553	0,447	N. Pivac, P. Pregel, M. Nikolac, T. Zupanc, G. Nedic, D. Muck Seler and A. Videtic Paska, The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide. Genes, Brain and Behavior (2011) 10: 565–569
Европа	basque,	Spain	cheek swabs or whole blood	Basque Country, Vitoria (статья)	42,5	-2,4	253	0,488	0,512	Manuel Fernández Martínez, Xabier Elcoroaristizabal Martín, Luís Galdos Alcelay, Jessica Castro Flores, Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Ángeles Gómez Beldarraín,Josefa Moraza López, María Carmen Gonzalez-Fernández, Ana Molano Salazar, Rocio Bereincua Gandarias, Sandra Inglés Borda, Nuria Ortiz Marqués, Miryam Barandiarán Amillano, María Carrasco Zabaleta and Marian M de Pancorbo. The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers. BMC Neuroscience 2009, 10:125
Европа	catalans	Spain	blood	Catalonia, Barcelona (статья)	41,2	2,1	188	0,524	0,476	Amalia Lafuente, Miquel Bernardo, Sergi Mas, Anna Crescenti, Monica Aparici, Patricia Gasso, Ramon Deulofeu, Anna Mane, Rosa Catalan, Xavier Carne. Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141C Ins/Del) and dopamine degradation enzyme (COMT G158A, A-278G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar disorders. Psychiatry Research 161 (2008) 131–141.
Европа	spanish	Spain		Madrid (ALFRED)	40,2	-3,4	113	0,570	0,430	Gutierrez B, Bertranpetit J, Guillamat R, Valles V, Arranz MJ, Kerwin R, Fananas L. "Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder. ". Am J Psychiatry 154:113-5. . (1997)
Европа	spanish	Spain	?	Valencia (статья)	39,3	0,2	405	0,559	0,442	Javier Costas , Julio Sanjuán, Ramón Ramos-Ríos, Eduardo Paz, Santiago Agra , José Luis Ivorra, Mario Páramo, Julio Brenlla, Manuel Arrojo. Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: New data and meta-analysis. Journal of Psychiatric Research 45 (2011) 7-14
Европа	spanish	Spain	?	Santiago de Compostela (статья)	42,6	-8,3	620	0,552	0,448	Javier Costas , Julio Sanjuán, Ramón Ramos-Ríos, Eduardo Paz, Santiago Agra , José Luis Ivorra, Mario Páramo, Julio Brenlla, Manuel Arrojo. Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: New data and meta-analysis. Journal of Psychiatric Research 45 (2011) 7-14
Европа	spanish	Spain	cheek swabs or whole blood	Madrid (статья)	40,2	-3,4	186	0,516	0,484	M. Gabrovsek, M. Brecelj-Anderluh, L. Bellodi, E. Cellini, D. Di Bella, X. Estivill, F. Fernandez-Aranda, B. Freeman, F. Geller, M. Gratacos, R. Haigh, J. Hebebrand, A. Hinney, J. Holliday, X. Hu, A. Karwautz, B. Nacmias, M. Ribases, H. Remschmidt, R. Komel, S. Sorbi, M. Tomori, J. Treasure, G. Wagner, J. Zhao, and D.A. Collier Combined Family Trio and Case-Control Analysis of the COMT Val158Met Polymorphism in European Patients With Anorexia Nervosa. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 124B:68–72 (2004)
Европа	turkish	Turkey	healthy, unrelated Turkish men and women with a mean age of 42	Ankara (ALFRED)	39,5	32,5	217	0,550	0,450	Kocabas NA, Karakaya AE, Cholerton S, Sardas S. "Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population". Arch Toxicol. 75:407-9. . (2001)
Европа	turks	Turkey	Women, peripheral venous blood	Istanbul, Erenkoy (статья)	41,0	28,6	341	0,585	0,416	Ali Sazcia, Emel Ergul, Ismail Kucukali, Gamze Kili, Guner Kaya, Ihsan Kara Catechol-O-methyltransferase gene Val108/158Met polymorphism, and susceptibility to schizophrenia: association is more significant in womenMolecular Brain Research 132 (2004) 51–56
Европа	turks	Turkey	Women, peripheral venous blood	Kocaely, Izmit (статья)	40,5	29,6	233	0,578	0,423	Ali Sazcia, Emel Ergul, Nihat Zafer Utkan, Nuh Zafer Canturk, Guner Kaya Catechol-O-methyltransferase Val 108/158 Met polymorphism in premenopausal breast cancer patients Toxicology 204 (2004) 197–202
Европа	turks	Turkey	venous blood samples anticoagulatedwith EDTA	Istanbul (статья)	41,0	28,6	130	0,458	0,542	Gul Karacetin, Burcu Bayoglu , Mujgan Cengiz, Turkay Demir, Nese Kocabasoglu, Omer Uysal, Reha Bayar, Ibrahim Balcioglu Serotonin-2 receptor and catechol-O-methyltransferase polymorphisms in panic disorder Progress in Neuro-Psychopharmacology & Biological Psychiatry 36 (2012) 5–10
Европа	turks	Turkey	peripheral blood leukocytes	Gazientep (статья)	37,0	37,2	79	0,427	0,574	Hasan Herken, M. Emin Erdal, Ömer Böke, Haluk A. Savas¸ Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene. European Psychiatry 18 (2003) 77–81.
Азия	persian                     (maybe total iranian)	Iran	saliva samples	Tegeran	35,4	51,3	76	0,463	0,537	Shabnam Nohesara, Mohammad Ghadirivasfi, Sahar Mostafavi, Mohammad-Reza Eskandari, Hamid Reza Ahmadkhaniha, Sam Thiagalingam, Hamid Mostafavi Abdolmaleky. DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder. Journal of Psychiatric Research 45 (2011) 1432-1438
Азия	khanty	Russia	North Khanty sub-ethnic group and the Kazum territorial group	Belojarsk area on the tributary of the Ob River and River Kazum (ALFRED)	53,3	83,5	50	0,580	0,420	Kenneth K. Kidd et al. "Data unpublished"
Азия
Азия	bengali	India	Peripheral blood	Bankura (статья)	23,2	87,0	96	0,567	0,433	Manali Das, Aneek Das Bhowmik, Nipa Bhaduri , Kanyakumarika Sarkar, Paramita Ghosh, Swagata Sinha, Anirban Ray, Anindita Chatterjee, Kanchan Mukhopadhyay. Role of gene–gene/gene–environment interaction in the etiology of eastern Indian ADHD probands. Progress in Neurо-Psychopharmacology & Biological Psychiatry 35 (2011) 577–587
Азия	total indian south	India	Peripheral blood	Karnataka, Bangalor (статья)	12,6	77,3	225	0,560	0,440	Aneek Das Bhowmik, Subhramay Chaudhury, Samikshan Dutta, Jyoti Shaw , Arpita Chatterjee, Arnab Choudhury, Amrita Saha, Dipanjana Sadhukhan , Turban Kar, Swagata Sinha, Kanchan Mukhopadhyay. Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability. Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 1714–1722
Азия	balochi	Pakistan	Pakistan, part of HGDP	Quetta, Balochistan Province (Википедия)	30,1	67,1	25	0,460	0,540	?
Азия	brahui	Pakistan	Pakistan, part of HGDP	Kalat (Википедия)	29,0	66,4	25	0,580	0,420	?
Азия	burusho	Pakistan	Pakistan, part of HGDP	Gilgit, Gilgit-Baltistan, (Википедия)	35,6	74,2	25	0,520	0,480	?
Азия	hazara	Pakistan	Pakistan, part of HGDP	Quetta, Balochistan Province, (Википедия)	30,1	67,1	24	0,480	0,520	?
Азия	kalash	Pakistan	Pakistan, part of HGDP	Chitral, Chitral District, (Википедия)	35,5	71,5	25	0,460	0,540	?
Азия	pashtun	Pakistan	Pakistan, part of HGDP	Peshawar, Federally Administered Tribal Areas (Википедия)	34,0	71,4	23	0,590	0,410	?
Азия	singhi	Pakistan	Pakistan, part of HGDP	Karachi, Sindh Province (Википедия)	24,5	67,0	25	0,580	0,420	?
Азия	keralite	USA	immigrants, Connecticut (USA)	Southwestern India, Kerala (ALFRED)	8,5	77,0	30	0,786	0,214	Kenneth K. Kidd et al. "Data unpublished"
Азия	chinese	China	?	Qinba region, Xi’an (статья)	34,2	108,5	305	0,740	0,260	Kejin Zhang, Zijian Zheng, Xiaocai Gao, Jing Li ,Fuchang Zhang. Possible Relationship between the COMT Gene Vel 158 Met Polymorphism and Psychometric IQ in Girls of the Qinba Region in China Neuropsychobiology 2007;56:98–103
Азия	chinese	China	Venous blood	Shaanxi,  Xi'an (статья)	34,2	108,5	549	0,762	0,238	Lin Gao, Hong Li, Kai Li, Zhu Shen, Ling Liu, Chunying Li, Zhengdong Zhang and Yufeng Liu. Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris. Genetics and Molecular Biology, 32, 1, 32-36 (2009)
Азия	chinese	China	Whole blood	Sichuan, Chengdu (статья)	30,4	104,0	400	0,715	0,285	Qiong Wang, Hui Li, Ping Tao, Yuan-Ping Wang, Ping Yuan, Chun-Xia Yang, Jia-Yuan Li, Fei Yang, Hui Lee, and Yuan Huang. Soy Isoflavones, CYP1A1, CYP1B1, and COMT Polymorphisms, and Breast Cancer: A Case–Control Study in Southwestern China. DNA AND CELL BIOLOGY. Volume 30, Number 8, 2011
Азия	chinese	China	venous blood	Beijing (статья)	39,5	116,2	194	0,711	0,289	Qiujin Qian, Yufeng Wang, Rulun Zhou, Jun Li, Bing Wang, Stephen Glatt, Stephen V. Faraone. Family-Based and Case-Control Association Studies of Catechol-O-Methyltransferase in Attention Deficit Hyperactivity Disorder Suggest Genetic Sexual Dimorphism. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 118B:103–109 (2003)
Азия	chinese	China	?	Qingdao (статья)	36,0	120,2	403	0,221	0,779	Shiguo Liu, Yanhui Liu, Haiping Wang, Ruiling Zhou, Jinbao Zong, Changgui Li, Xinhua Zhang, and Xu Ma. Association of Catechol-O-Methyl Transferase (COMT) Gene  287A/G Polymorphism With Susceptibility to Obsessive–Compulsive Disorder in Chinese Han Population. AMERICAN JOURNAL OF MEDICAL GENETICS PART B
Азия	chinese	China		Yunnan (ALFRED)	24,3	101,3	214	0,720	0,280	Wang X, Zhong S, Gao L, Dou S, He G, Ran Y, Bao J, Jing Q. "An association study between polymorphism of alcohol dehydrogenase(ADH1B), aldehyde dehydrogenase(ALDH2), cytochrome(CYP4502E1), Catechol-o-Methyltransferase (COMT) and 5-hydroxytryptamine transporter(5-HTT) genes in Yunnan Han population with alcohol dependence". African Journal of Biotechnology 10:12164-12170. (2011)
Азия	chinese	China	blood	Harbin (статья)	45,5	126,4	320	0,461	0,539	Yang Cao Dawei Wang Bin Liu Guijun Yao Yutuo Fu Zhenggang Bi. Catechol-O-methyltransferase (COMT) Val158Met polymorphism and risk of osteoporotic fracture. Mol Biol Rep (2012) 39:6811–6823
Азия	japanese	Japan	buccal	Tokyo (статья)	35,4	139,4	369	0,713	0,288	Chikako Kiyohara, Yoshihiro Miyake, Midori Koyanagi, Takahiro Fujimoto, Senji Shirasawa, Keiko Tanaka, Wakaba Fukushima, Satoshi Sasaki, Yoshio Tsuboi, Tatsuo Yamada, Tomoko Oeda, Hiroyuki Shimada,Nobutoshi Kawamura, Nobutaka Sakae, Hidenao Fukuyama, Yoshio Hirota and Masaki Nagai, for Fukuoka Kinki Parkinson’s Disease Study Group. Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson’s disease in a Japanese population. Kiyohara et al. BMC Neurology 2011, 11:89
Азия	japanese	Japan	peripheral leucocytes	Yamagata (статья)	38,2	140,2	478	0,722	0,278	Genki Ishii, Akihito Suzuki, Shingo Oshino, Hiroaki Shiraishi,Yoshihiko Matsumoto, Koichi Otani, Kaoru Goto. Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in Japanese healthy volunteers. European Psychiatry 22 (2007) 462-465
Азия	japanese	Japan	unrelated Japanese men and women who reported themselves in good health	Tokyo (столица)	35,4	134,4	153	0,710	0,290	Kunugi H, Nanko S, Ueki A, Otsuka E, Hattori M, Hoda F, Vallada HP, Arranz MJ, Collier DA. "High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease". Neurosci Lett. 221:202-4. . (1997)
Азия	japanese	Japan	men, venous blood	Tokyo (статья)	35,4	139,4	838	0,646	0,354	Mineyoshi Hiyoshi , Hirokazu Uemura, Kokichi Arisawa, Mariko Nakamoto,Asahi Hishida, Rieko Okada, Keitaro Matsuo, Yoshikuni Kita, Hideshi Niimura, Nagato Kuriyama, Hinako Nanri ,Keizo Ohnaka, Sadao Suzuki, Haruo Mikami , Michiaki Kubo , Hideo Tanaka, Nobuyuki Hamajima and for the J-MICC Study Group Association between the catechol-O-methyltransferase (rs4680: Val158Met)polymorphism and serum alanine aminotransferase activity. Gene 496 (2012) 97–102
Азия	japanese	Japan	women, venous blood	Tokyo (статья)	35,4	139,4	970	0,640	0,361	Mineyoshi Hiyoshi , Hirokazu Uemura, Kokichi Arisawa, Mariko Nakamoto,Asahi Hishida, Rieko Okada, Keitaro Matsuo, Yoshikuni Kita, Hideshi Niimura, Nagato Kuriyama, Hinako Nanri ,Keizo Ohnaka, Sadao Suzuki, Haruo Mikami , Michiaki Kubo , Hideo Tanaka, Nobuyuki Hamajima and for the J-MICC Study Group Association between the catechol-O-methyltransferase (rs4680:  Val158Met)polymorphism and serum alanine aminotransferase activity. Gene 496 (2012) 97–102
Азия	japanese	Japan	Japapese men and women above the age of 45 years	Kyushu (ALFRED)	33,0	131,0	150	0,730	0,270	Ohmori O, Shinkai T, Kojima H, Terao T, Suzuki T, Mita T, Abe K. "Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics". Neurosci Lett. 243:109-12. (1998)
Азия	japanese	Japan	total blood	Tokyo (статья)	35,4	139,4	201	0,687	0,313	Toshiya Inada, Ataru Nakamura, and Yoshimi Iijima. Relationship Between Catechol-O-Methyltransferase Polymorphism and Treatment-Resistant Schizophrenia. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 120B:35–39 (2003)
Азия	mongolian	Mongolia	part of HGDP	Ulan Bator (столица)	47,6	106,6	10	0,750	0,250	?
Азия	yakut	Russia	Yakutia	Yakutsk (ALFRED)	62,0	129,4	51	0,696	0,304	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Азия	koreans	South Korea	?	Seoul (столица)	37,3	126,6	396	0,742	0,258	Byung Lae Park, Hyoung Doo Shin, Hyun Sub Cheong, Chul Soo Park, Jin-Wook Sohn, Bong-Jo Kim, Han-Kil Seo, Jae Won Kim, Ki-Hoon Kim, Tae-Min Shin, Ihn-Geun Choi, Shin Gyeom Kim and Sung-Il Woo. Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality. Journal of Human Genetics (2009) 54, 709–712
Азия	koreans	South Korea	white blood cell fractions	Busan (статья)	35,1	129,0	348	0,742	0,259	Kang HJ, Choe BM, Kim SH, Son SR, Lee KM, Kim BG, Hong YS. No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population. Epidemiol Health. 2010, 32:e2010011.
Азия	koreans	South Korea	woman, blood	Ansan (статья)	37,2	126,5	85	0,724	0,276	Hwa-Young Lee Yong-Ku Kim . Gender Effect of Catechol- O Methyltransferase Val158Met Polymorphism on Suicidal Behavior Neuropsychobiology 2011;63:177–183
Азия	koreans	South Korea	blood leukocytes	Seoul (столица)	37,3	126,6	157	0,666	0,335	Hwa-Young Lee, Yong-Ku Kim. Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients. Psychiatry Research 175 (2010) 63–66
Азия	koreans	South Korea	men, blood	Ansan (статья)	37,2	126,5	85	0,588	0,412	Hwa-Young Lee, Yong-Ku Kim. Gender Effect of Catechol- O Methyltransferase Val158Met Polymorphism on Suicidal Behavior. Neuropsychobiology 2011;63:177–182
Азия	koreans	South Korea	blood sample	Seoul (столица)	37,3	126,6	277	0,718	0,282	Jee In Kang, Dong-Ho Song, Kee Namkoong, Se Joo Kim. Interaction effects between COMT and BDNF polymorphisms on boredom susceptibility of sensation seeking traits. Psychiatry Research 178 (2010) 132–136
Азия	koreans	South Korea	peripheral blood leukocytes	Seoul (столица)	37,3	126,6	184	0,730	0,271	Jee In Kang, Kee Namkoong, Ra Yeon Ha, Kyungun Jhung, Yang Tae Kim, Se Joo Kim Influence of BDNF and COMT polymorphisms on emotional decision making. Neuropharmacology 58 (2010) 1109e1113
Азия	koreans	South Korea	blood sample	Seoul (столица)	37,3	126,6	241	0,704	0,297	Jee In Kang, Se Joo Kim, Kee Namkoong, Suk Kyoon An. Association of DRD4 and COMT Polymorphisms with Disgust Sensitivity in Healthy Volunteers. Neuropsychobiology 2010;61:105–112
Азия	koreans	South Korea	unrelated individuals	Seoul (ALFRED)	37,5	127,0	54	0,722	0,278	Kenneth K. Kidd et al. "Data unpublished"
Азия	koreans	South Korea	blood leukocytes	Seoul (столица)	37,3	126,6	409	0,710	0,290	Youl-Ri Kim, Jeong Hyun Kim, Se Joo Kim, Dongeun Lee, Sung Kil Min.Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population. European Neuropsychopharmacology (2008) 18, 820–825
Азия	ami	Taiwan	males	between the Central Mountains and the Coastal Mountains, Yu-li (ALFRED)	23,2	121,2	42	0,821	0,179	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Азия	atayal	Taiwan		Taroko, Hualien area of Taiwan, (ALFRED)	24,0	121,0	41	0,817	0,183	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Азия	chinese	Taiwan	chinese in Taiwan	Taipei, Taiwan, (ALFRED)	25,0	121,4	188	0,731	0,269	Liou YJ, Tsai SJ, Hong CJ, Wang YC, Lai IC. "Association analysis of a functional catechol-o-methyltransferase gene polymorphism in schizophrenic patients in Taiwan". Neuropsychobiology. 43:11-4. . (2001)
Азия	chinese (Taiwanish)	Taiwan	peripheral blood leukocytes	Taipei (столица)	25,0	121,4	442	0,734	0,266	C.-Y. Chen, R.-B. Lu, Y.-W. Yeh, M.-C. Shih and S.-Y. Huang Association study of catechol-O-methyltransferase gene polymorphisms with schizophrenia and psychopathological symptoms in Han Chinese. Genes, Brain and Behavior (2011) 10: 316–324
Азия	chinese (Taiwanish)	Taiwan	woman, peripheral blood	Taipei (статья)	25,0	121,4	150	0,733	0,267	Chiun-Sheng Huang, Herng-Der Chern, King-Jen Chang, Chun-Wen Cheng, Su-Ming Hsu, and Chen-Yang Shen Estrogen-metabolizing Genes CYP17, CYP1A1, and COMT: A Multigenic Study on Cancer Susceptibility CANCER RESEARCH 59, 4870–4875, October 1, 1999
Азия	chinese (Taiwanish)	Taiwan	men	Taipei (статья)	25,0	121,4	161	0,736	0,264	Mu-En Liu, Chen-Jee Honga , Ying-Jay Liou , Yung-Lang Tsai, Cheng-Hsi Hsiehe, Shih-Jen Tsai Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia. Neuroscience Letters 436 (2008) 193–195
Азия	chinese (Taiwanish)	Taiwan	buccal mucosa cells inner surface of the cheek	Taipei (статья)	25,0	121,4	191	0,775	0,225	R.M. Wu, MD, PhD; C.W. Cheng, PhD; K.H. Chen, PhD; S.L. Lu, MSc; D.E. Shan, MD, PhD; Y.F. Ho, MD, PhD; and H.D. Chern, MD, PhD. The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese. Neurology 2001;56;375
Азия	chinese (Taiwanish)	Taiwan	peripheral blood	Taipei (статья)	25,0	121,4	198	0,786	0,214	S.H.Juo, T.N.Wang, J.N.Lee, M.T.Wu, C.Y.Long and E.M.Tsai CYP17, CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women Human Reproduction Vol.21, No.6 pp. 1498–1502, 2006
Азия	chinese (Taiwanish)	Taiwan	venous blood lymphocytes	Taipei (столица)	25,0	121,4	236	0,758	0,242	SHENG-YU LEE, SHIOU-LAN CHEN, SHIH-HENG CHEN, SAN-YUAN HUANG, NIAN-SHENG TZENG, YUN-HSUAN CHANG, CHEN-LIN WANG, I HUI LEE, TZUNG LIEH YEH, YEN KUANG YANG & RU-BAND LU The COMT and DRD3 genes interacted in bipolar I but not bipolar II disorder. The World Journal of Biological Psychiatry, 2011; 12: 385–391
Азия	chinese (Taiwanish)	Taiwan	woman, peripheral leukocytes	Taipei (статья)	25,0	121,4	120	0,771	0,229	Shih-Jen Tsai Chen-Jee Honga, Younger W.-Y. Yuc Tai-Jui Chend, Association Study of Catechol-O-Methyltransferase Gene and Dopamine D4 Receptor Gene Polymorphisms and Personality Traits in Healthy Young Chinese Females. Neuropsychobiology 2004;50:153–156
Азия	chinese (Taiwanish)	Taiwan	peripheral leukocytes	Taipei (столица)	25,0	121,4	254	0,740	0,260	Tien-Wen Lee, Younger W-Y Yuc, Chen-Jee Hong, Shih-Jen Tsai, Hung-Chi Wu, Tai-Jui Chen. The effects of catechol-O-methyl-transferase polymorphism Val158Met on functional connectivity in healthy young females: A resting EEG study. B R A I N R E S E A R C H 1 3 7 7 ( 2 0 1 1 ) 2 1 – 3 1
Азия	chinese (Taiwanish)	Taiwan	peripheral blood+buffy coat cells	Taipei (столица)	25,0	121,4	740	0,745	0,255	Ting-Chih Cheng, Shou-Tung Chen, Chiun-Sheng Huang, Yi-Ping Fu, Jyh-Cherng Yu, Chun-Wen Cheng, Pei-Ei Wu and Chen-Yang Shen. Breast Cancer Risk Associated With Genotype Polymorphism of the Catechol Estrogen-Metabolizing Genes: A Multigenic Study on Cancer Susceptibility. Int. J. Cancer: 113, 345–353 (2005)
Азия	chinese (Taiwanish)	Taiwan	?	Taipei (столица)	25,0	121,4	779	0,711	0,289	Ting-Kuang Yeh, Chun-Yen Chang , Chung-Yi Hud, Ting-Chi Yeh, Ming-Yeh Lin  Association of catechol-O-methyltransferase (COMT) polymorphism and academic achievement in a Chinese cohort. Brain and Cognition 71 (2009) 300–305
Азия	chinese (Taiwanish)	Taiwan	blood	Taipei (статья)	25,0	121,4	341	0,752	0,248	Wei-Yu Lin MS, Yu-Ching Chou MS, Mei-Hsuan Wu MS, Yi-Lin Jeng MS, Han-Bin Huang MS, San-Lin You PhD, Tang-Yuan Chu PhD, Chien-Jen Chen ScD, Chien-An Sun ScD  Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: A nested case–control study in Taiwan. Cancer Detection and Prevention 29 (2005) 427–432
Азия	chinese (Taiwanish)	Taiwan	Yuli + Pali, peripheral white blood cells	Taipei (столица)	25,0	121,4	133	0,733	0,267	I.-C. Lai, Y.-C. Wang, C.-C. Lin, Y.-M. Bai, D.-L. Liao, S.-C. Yu, C.-Y. Lin, J.-Y. Chen, and Y.-J. Liou Negative association between Catechol-O methyltransferase (COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophreni. J Neural Transm (2005) 112: 1107–1113
Азия	chinese	Singapore	saliva	Singapore	1,2	103,5	350	0,733	0,267	Julian Lim , Richard Ebstein , Chun-Yu Tse, Mikhail Monakhov, Poh San Lai, David F. Dinges, Kenneth Kwok. Dopaminergic Polymorphisms Associated with Time-on-Task Declines and Fatigue in the Psychomotor Vigilance Test
Азия	chinese	Singapore	Women, Blood and/or saliva	Singapore	1,2	103,5	1578	0,752	0,248	Wei-Yen Lim, Ying Chen, Khoon Leong Chuah, Philip Eng, Swan Swan Leong, Elaine Lim, Tow Keang Lim, Alan Ng, Wee Teng Poh, Augustine Tee, Ming Teh, Agus Salim, and Adeline Seow. Female Reproductive Factors, Gene Polymorphisms in the Estrogen Metabolism Pathway, and Risk of Lung Cancer in Chinese Women. Am J Epidemiol. 2012;175(6):492–503
Азия	cambodian	Cambodia	individuals born in Cambodia who are now living in Santa Ana, California	Phnom Penh (столица)	11,3	104,6	26	0,720	0,280	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Азия	lao	Lao People's Democratic Republic	from all over the country Lao People's Democratic Republic	Vientiane (столица)	17,6	102,4	113	0,779	0,221	Kenneth K. Kidd et al. "Data unpublished"
Азия	chinese (malaysian)	Malaysia	blood	Kuala-Lampur (статья)	3,1	101,4	154	0,759	0,241	Ching-Lee Wan, Nor Zuraida Zainal, Lay-Hoong Lian, Zahurin Mohamed. Association of the functional polymorphism in the catechol-O methyltransferase gene with schizophrenia in the three ethnic groups of the Malaysian population. Psychiatry Research 189 (2011) 67–71
Азия	indians (malaysian)	Malaysia	blood	Kuala-Lampur (статья)	3,1	101,4	84	0,651	0,349	Ching-Lee Wan, Nor Zuraida Zainal, Lay-Hoong Lian, Zahurin Mohamed. Association of the functional polymorphism in the catechol-O methyltransferase gene with schizophrenia in the three ethnic groups of the Malaysian population. Psychiatry Research 189 (2011) 67–71
Азия	malays	Malaysia	blood	Kuala-Lampur (статья)	3,1	101,4	79	0,734	0,266	Ching-Lee Wan, Nor Zuraida Zainal, Lay-Hoong Lian, Zahurin Mohamed. Association of the functional polymorphism in the catechol-O methyltransferase gene with schizophrenia in the three ethnic groups of the Malaysian population. Psychiatry Research 189 (2011) 67–71
Азия	malays	Malaysia	peripheral blood sample	Perak, Ipoh (статья)	4,4	101,4	261	0,719	0,281	Shiau Foon Tee, Pek Yee Tang, Han Chern Loh. COMT haplotype analyses in Malaysians with schizophrenia. Psychiatry Research 195 (2012) 83–84
Азия	pilipino (total)	Philippines			выборка из США (см. ниже)	выборка из США (см. ниже)	166	0,775	0,225	Anna H. Wu, Chiu-Chen Tseng, David Van Den Berg, et al. Tea Intake, COMT Genotype, and Breast Cancer in Asian-American Women. Cancer Res 2003;63:7526-7529
Азия	khon-tai	Thailand	buffy coats	Bangkok +              Khon Kaen, Province of North Eastern Thailand (статья)	13,5	100,3	497	0,750	0,250	Suleeporn Sangrajrang, Yasunori Sato, Hiromi Sakamoto, Sumiko Ohnami, Nan M. Laird, Thiravud Khuhaprema, Paul Brennan, Paolo Boffetta and Teruhiko Yoshida. Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. Int. J. Cancer: 125, 837–843 (2009)
Азия	asian american (chinese)	USA	women, buffy coats of peripheral blood	Los Angles (статья)	34,0	-118,2	199	0,729	0,271	Anna H. Wu, Chiu-Chen Tseng, David Van Den Berg, et al. Tea Intake, COMT Genotype, and Breast Cancer in Asian-American Women. Cancer Res 2003;63:7526-7529
Азия	asian american (filipino)	USA	women, buffy coats of peripheral blood	Los Angles (статья)	34,0	-118,2	197	0,657	0,343	Anna H. Wu, Chiu-Chen Tseng, David Van Den Berg, et al. Tea Intake, COMT Genotype, and Breast Cancer in Asian-American Women. Cancer Res 2003;63:7526-7529
Азия	asian american (japanese)	USA	women, buffy coats of peripheral blood	Los Angles (статья)	34,0	-118,2	166	0,775	0,225	Anna H. Wu, Chiu-Chen Tseng, David Van Den Berg, et al. Tea Intake, COMT Genotype, and Breast Cancer in Asian-American Women. Cancer Res 2003;63:7526-7529
Океания	australian        european	Australia	saliva	Brisbane (статья)	-27,3	153,0	250	0,443	0,557	J. Voisey, C.D.Swagell, I.P.Hughes, B.R.Lawford, R.M.Young, C.P.Morris. HapMap tag-SNPanalysisconfirmsarolefor COMT in schizophreniariskand reveals anovelassociation. J. Voiseyetal./EuropeanPsychiatryxxx(2010)xxx–xxx
Океания	australian        european	Australia	blood collection	Brisbane (статья)	-27,3	153,0	430	0,483	0,518	Patricia A. Brennan, Ph.D., Emory University Constance Hammen, Ph.D., University of California, Los Angeles Patrick Sylvers, Ph.D.,Emory University William Bor, M.B.B.S., F.R.A.N.Z.C.P., Mater Misericordiae Children’s Hospital, South Brisbane, Australia Jake Najman, Ph.D., University of Queensland, Australia Penelope Lind, Ph.D., Queensland Institute of Medical Research, Brisbane, Australia Grant Montgomery, Ph.D., and Queensland Institute of Medical Research, Brisbane, Australia Alicia K. Smith, Ph.D. Emory University. Interactions Between the COMT Val108/158Met Polymorphism and Maternal Prenatal Smoking Predict Aggressive Behavior Outcomes. Biol Psychol. 2011 April ; 87(1): 99–105.
Океания	white                      new zelanders	New Zeland	buccal swabs	Dunedin (статья)	-45,5	170,3	1037	0,500	0,500	Avshalom Caspi, PhD; Kate Langley, PhD; Barry Milne, MSc; Terrie E. Moffitt, PhD; Michael O’Donovan, MD; Michael J. Owen, MD; Monica Polo Tomas, MSc; Richie Poulton, PhD; Michael Rutter, MD; Alan Taylor, MSc; Benjamin Williams, BSc; Anita Thapar, MD. A Replicated Molecular Genetic Basis for Subtyping Antisocial Behavior in Children With Attention-Deficit/Hyperactivity Disorder. Arch Gen Psychiatry. 2008;65(2):203-210
Океания
Океания	melanesian, nasioi	Bougainville Island, Solomon Islands		Honiara (столица Solomon Islands)	-9,3	159,5	23	0,739	0,261	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Океания	papuan new guinea	Papua New Guinea	part of HGDP	Port Moresby (столица)	-9,3	147,2	17	0,560	0,440	?
Океания	micronesian	Micronesia	several different islands in Micronesia.	центр региона Micronesia (Википедия)	6,0	147,0	39	0,865	0,135	?
Океания	hawaian	USA	Caucasian 29%, Asian (Japanese, Chinese, Filipino, Korean) 48%, Native Hawaiian+ Samoan 23%; female, peripheral blood leukocytes	Oahu (статья)			144	0,670	0,330	Marc T. Goodman, Katharine McDuffie, Laurence N. Kolonel, Keith Terada, Timothy A. Donlon, Lynne R. Wilkens, Chuanfa Guo, and Loı¨c Le Marchand. Case-Control Study of Ovarian Cancer and Polymorphisms in Genes Involved in Catecholestrogen Formation and Metabolism. Cancer Epidemiology, Biomarkers & Prevention. Vol. 10, 209–216, March 2001
Океания	hawaian	USA	Caucasian 32.4% Japanese 46.8% Native Hawaiian 30%; blood sample	Honolulu (статья)			250	0,596	0,404	Yumie Takata, Gertraud Maskarinec and Loïc Le Marchand. Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the Multiethnic Cohort. BMC Cancer 2007, 7:30
Сев. Америка	Сandian          european origin	Canada	Women	Ontario, Toronto (столица)	43,2	-79,2	719	0,530	0,471	Ummiye V Onay, Kirsimari Aaltonen, Laurent Briollais, Julia A Knight, Noel Pabalan, Outi Kilpivaara, Irene L Andrulis, Carl Blomqvist, Heli Nevanlinna and Hilmi Ozcelik. Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk. BMC Cancer 2008,
Сев. Америка	white american	USA	?	Boston (статья)			467	0,475	0,525	Birgit Funke, Anil K Malhotra, Christine T Finn, Alex M Plocik, Stephen L Lake, Todd Lencz, Pamela DeRosse, John M Kane and Raju Kucherlapati. COMT genetic variation confers risk for psychotic and affective disorders: a case control study. Behavioral and Brain Functions 2005, 1:19
Сев. Америка	white american	USA	woman, cord blood	Minnesota, Minneapolis (статья)			194	0,450	0,550	Chandrasekhar Thota, PhD, Ramkumar Menon, PhD, Melissa J. Wentz, PhD, Stephen J. Fortunato, MD, Jackie Bartlett, MS, Cayce O. Drobek, BS, Sangeeta Nair, MS and Ayman Al-Hendy, MD, PhD. A Single-Nucleotide Polymorphism in the Fetal Catechol-O-methyltransferase Gene is Associated With Spontaneous Preterm Birth in African Americans.Reproductive Sciences 19(2) 135-142
Сев. Америка	white american	USA	smokers, peripheral blood	Tennessee, Mississippi, Arkansas (статья)			671	0,270	0,730	Joke Beuten, Thomas J Payne, Jennie Z Ma and Ming D Li. Significant Association of Catechol-O-Methyltransferase (COMT) Haplotypes with Nicotine Dependence in Male and Female Smokers of Two Ethnic Populations. Neuropsychopharmacology (2006) 31, 675–684
Сев. Америка	white american	USA	women, peripheral blood leukocytes or epithelial cells from the buccal mucosa	Washington (статья)			246	0,513	0,487	M.A. Hernán, MD, DrPH; H. Checkoway, PhD; R. O’Brien, BS; P. Costa–Mallen, PhD; I. De Vivo, PhD, MPH; G.A. Colditz, MD, DrPH; D.J. Hunter, MB, BS, ScD; K.T. Kelsey, MD, MOH; A. Ascherio, MD, DrPH. MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD. Neurology 2002;58;1381
Сев. Америка	white american	USA	men, peripheral blood leukocytes or epithelial cells from the buccal mucosa	Washington (статья)			203	0,498	0,503	M.A. Hernán, MD, DrPH; H. Checkoway, PhD; R. O’Brien, BS; P. Costa–Mallen, PhD; I. De Vivo, PhD, MPH; G.A. Colditz, MD, DrPH; D.J. Hunter, MB, BS, ScD; K.T. Kelsey, MD, MOH; A. Ascherio, MD, DrPH. MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD. Neurology 2002;58;1381
Сев. Америка	white american	USA	peripheral blood leukocytes	North Carolina (статья)			379	0,470	0,530	Robert C. Millikan, Garry S. Pittman, Chiu Kit Tse, Eric Duell, Beth Newman, David Savitz, Patricia Moorman, Robert J.Boissy, Duglas A. Bell. Cathol-O-methyltransferase and breast cancer.Carcinogenesis. V 19. N 11. P. 1943-1947.2001
Сев. Америка	white american	USA	immortalized cell lines, but some samples from blood or saliva	New Haven, Farmigton, Belmont, Charlestone (статья)			707	0,520	0,480	Rungnapa Ittiwut, Jennifer B. Listman, Chupong Ittiwut, Joseph F. Cubells, Roger D. Weiss, Kathleen Brady, David Oslin, Lindsay A. Farrer, Henry R. Kranzler, and Joel Gelernter. Association Between Polymorphisms in Catechol-Omethyltransferase (COMT) and Cocaine-Induced Paranoia in European-American and African-American Populations.AMERICAN JOURNAL OF MEDICAL GENETICS PART B
Сев. Америка	white american	USA	(93%) non-Hispanic caucasian                women; 517 of whom provided blood and 76, buccal cells	Seattle (статья)			593	0,490	0,510	Thanh GN Ton, Mary Anne Rossing, Deborah J Bowen, Sengkeo Srinouanprachan, Kristine Wicklund and Federico M Farin. Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. Behavioral and Brain Functions 2007, 3:22
Сев. Америка	white american caucasian	USA	buccal epithelial cells sample 1	Virginia (статья)			351	0,482	0,519	John M. Hettema, MD, PhD, Seon-Sook An, PhD, Jozsef Bukszar, PhD, Edwin J.C.G. van den Oord, PhD, Michael C. Neale, PhD, Kenneth S. Kendler, MD, and Xiangning Chen, PhD. COMT Contributes to Genetic Susceptibility Shared Among Anxiety Spectrum Phenotypes. Biol Psychiatry. 2008 August 15; 64(4): 302–310
Сев. Америка	white american caucasian	USA	buccal epithelial cells sample 2	Virginia (статья)			188	0,407	0,594	John M. Hettema, MD, PhD, Seon-Sook An, PhD, Jozsef Bukszar, PhD, Edwin J.C.G. van den Oord, PhD, Michael C. Neale, PhD, Kenneth S. Kendler, MD, and Xiangning Chen, PhD. COMT Contributes to Genetic Susceptibility Shared Among Anxiety Spectrum Phenotypes. Biol Psychiatry. 2008 August 15; 64(4): 302–310
Сев. Америка	white american caucasian   98% women	USA	buccal cytobrush and mouthwash	Washington (статья)			1.416	0,481	0,519	NEERAJA B. PETERSON, AMY TRENTHAM-DIETZ, MONTSERRAT GARCIA-CLOSAS, POLLY A. NEWCOMB, LINDA TITUS-ERNSTOFF, YIFAN HUANG, STEPHEN J. CHANOCK, JONATHAN L. HAINES, and KATHLEEN M. EGAN. Association of COMT Haplotypes and Breast Cancer Risk in Caucasian Women. Anticancer Res. 2010 January ; 30(1): 217–220
Сев. Америка
Сев. Америка	native american	U.S.                   Oklahoma	(Plain Indian) alcoholic 0,515% +healthy lymphoblast cell lines				342	0,710	0,290	Mary-Anne Enoch, Juwaria F. Waheed, Claudia R. Harris, Bernard Albaugh, and David Goldman. Sex Differences in the Influence of COMT Val158Met on Alcoholism and Smoking in Plains American Indians. ALCOHOLISM: CLINICAL AND EXPERIMENTAL RESEARCH. Vol. 30, No. 3 March 2006
Сев. Америка	cheyenne	USA		western Oklahoma, Guymon, (ALFRED)	36,4	-101,3	56	0,705	0,295	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Сев. Америка	pima	USA		Phoenix, Arizona area, (ALFRED)	33,4	-112,1	51	0,824	0,176	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Сев. Америка
Центр. Америка	mexicans	Mexico	whole blood	Mexico City (статья)	19,3	-99,8	33	0,670	0,330	Gilberto Vargas-Alarcón, José-Manuel Fragoso, David Cruz-Robles, Angélica Vargas, Alfonso Vargas, José-Ignacio Lao-Villadóniga, Ferrán García-Fructuoso, Manuel Ramos-Kuri, Fernando Hernández, Rashidi Springall, Rafael Bojalil, Maite Vallejo and Manuel Martínez- Lavín. Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. Arthritis Research & Therapy Vol 9 No 5
Центр. Америка	maya	Mexico	Mayans who are Yucatec speakers from in the Xmaben village	Mexico, Campeche, central Yucatan peninsula (ALFRED)	18,5	-90,2	53	0,462	0,538	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Центр. Америка	pima	Mexico		Sonora, Mexico, (ALFRED)	29,4	-110,5	53	0,651	0,349	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Центр. Америка	southwest amerindian	Mexico		Santa Fe, New Mexico, (ALFRED)	35,4	-105,6	45	0,633	0,367	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Юж. Америка	brazil	Brazil	children with ADHD without disruptive behavior disorders	Porto Alegre (статья)	-30,0	-51,0	252	0,470	0,530	Salatino-Oliveira A, Genro JP, Zeni C, Polanczyk GV, Chazan R, Guimarães AP, Callegari-Jacques SM, Rohde LA, Hutz MH. Catechol-O-methyltransferase valine158methionine polymorphism moderates methylphenidate effects on oppositional symptoms in boys with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2011 Aug 1;70(3):216-21. Epub 2011 May 6.
Юж. Америка	brazilian (unclassified)	Brazil	whole venous blood	Sao Paolo (статья)	-23,3	-46,38	335	0,646	0,354	N.M.M.Valente, H. Vallada, Q. Cordiero, R.A.Bressan, S.B.Andreoli, J.J. Mari, M.F. Mello. Catechol-O-methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD After Urban Violence. J Mol Neurosci. Oct. 2011. (43):516–523
Юж. Америка	xavante               (brazilian native american)	Brazil	Blood samples	Mato Grosso, Sangradouro, Cuiabá. (статья)	-15,4	-45,05	179	0,663	0,338	SUSANA N. SILVA, MARISA N. CABRAL, GUILHERME BEZERRA DE CASTRO, MARCELO PIRES, ANA PAULA AZEVEDO, ISABEL MANITA, JULIETA ESPERANÇA PINA, JOSÉ RUEFF and JORGE GASPAR Breast cancer risk and polymorphisms in genes involved in metabolism of estrogens (CYP17, HSD17ß1, COMT and MnSOD): Possible protective role of MnSOD gene polymorphism Val/Ala and Ala/Ala in women that never breast fed. ONCOLOGY REPORTS 16: 781-788, 2006
Юж. Америка	columbian mestizos	Colombia	peripheral blood	Bogota (статья)	4,2	-74,4	168	0,369	0,631	Diego A. Forero, Bruno Benı´tez, Gonzalo Arboleda, Juan J. Yunis, Rodrigo Pardo, Humberto Arboleda. Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer’s disease in Colombia
Юж. Америка	karitiana	Brazil	Karitiana village	Rondonia Province (ALFRED)	-8,4	-63,5	55	0,991	0,009	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Юж. Америка	surui	Brazil		Rondonia Province (ALFRED)	-8,4	-63,5	46	0,696	0,304	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Юж. Америка	ticuna	Brazil	several villages in the western part of Amazonas, Brazil	western part of Amazonas, Brazil (near Rio Salimas) (ALFRED)	-6,4	-69,5	67	0,784	0,216	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Юж. Америка	quechuan	Peru	more remote Andes and were judged by a local anthropologist to be typical Quechuan speakers	Lima, Peru (ALFRED)	-12,2	-77,1	22	0,591	0,409	?