Частоты аллелей в популяциях России и мира

Катехол-O-метилтрансфераза COMT

Val158Met

rs4680

 

Публикации:

Inglehart R.F., Borinskaya S., Cotter A., Harro J, Inglehart R.C., Ponarin E., Welzel C. Genetic factors, cultural predispositions, happiness and gender equality // Journal of Research in Gender Studies 2014 4 (1): 32-100

 

 

Регион	Популяция	Страна	Описание	Географическое описание	Широта (Latitude)	Долгота (Longitude)	N	Val-аллель  (H)         mut G	Met-аллель  (L)              mut A	Статья
Африка	Biaka	Central African Republic	3/4 "non-pygmy" African ancestry; 1/4 Mbuti ancestry	of Biaka, living in the village of Bagandu, in the southwest corner of the Central African Republic (3.42N; 18E altitude approximately 500m). (ALFRED)	3,4	18,0	70	0,943	0,057	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Африка	Mandenka	Central African Republic	Central African Republic, part of HGDP	Bangui (столица)	4,2	18,4	24	0,670	0,330	?
Африка	Mbuti	DR Congo	Nilosaharan and Niger Kordofanian speaking Mbuti pygmies	Ituri Forest, northeastern DR Congo (ALFRED)	-1,4	29,1	39	0,808	0,192	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Африка	Ewe	Ghana		Ghana, Volta Region, (центр региона, из Википедии)	7,0	0,3	32	0,700	0,300	Ameyaw MM, Syvanen AC, Ulmanen I, Ofori-Adjei D, McLeod HL. "Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population.". Hum Mutat. 16:445-6. . (2000)
Африка	Fanti	Ghana		Ghana, Central Region, (центр региона, из Википедии)	7,2	-2,2	37	0,770	0,230	Ameyaw MM, Syvanen AC, Ulmanen I, Ofori-Adjei D, McLeod HL. "Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population.". Hum Mutat. 16:445-6. . (2000)
Африка	Ga	Ghana		Accra (центр региона, из Википедии)	5,3	-0,1	46	0,800	0,200	Ameyaw MM, Syvanen AC, Ulmanen I, Ofori-Adjei D, McLeod HL. "Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population.". Hum Mutat. 16:445-6. . (2000)
Африка	Ghana	Ghana	ghanian (ewe, fanti, ga)	Accra (столица)	5,3	-0,1	190	0,740	0,260	Ameyaw MM, Syvanen AC, Ulmanen I, Ofori-Adjei D, McLeod HL. "Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population.". Hum Mutat. 16:445-6. . (2000)
Африка	kenyan (total)	Kenya		Nairoby (столица)	-1,2	36,5	102	0,680	0,320	McLeod HL, Syvänen AC, Githang'a J, Indalo A, Ismail D, Dewar K, Ulmanen I, Sludden J. Source Ethnic differences in catechol O-methyltransferase pharmacogenetics: frequency of the codon 108/158 low activity allele is lower in Kenyan than Caucasian or South-west Asian individuals.
Африка	Masai	Kenya	unrelated individuals belonging to the Masai tribe in East Africa. Groups of Masai live in Kenya and Tanzania	Ekenywa, Tanzanian-Kenyan border (ALFRED)	-2,0	36,0	20	0,675	0,325	Kenneth K. Kidd et al. "Data unpublished"
Африка	Hausa	Nigeria		Zaria, North Central Nigeria, (ALFRED)	11,0	7,4	39	0,737	0,263	Kenneth K. Kidd et al. "Data unpublished"
Африка	Ibo	Nigeria		Enugu, southeastern Nigeria, (ALFRED)	6,3	7,3	46	0,635	0,365	Kenneth K. Kidd et al. "Data unpublished"
Африка	Yoruba	Nigeria	urban health care workers	Benin City (столица)	6,3	5,6	78	0,652	0,348	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Африка	boer & afrikaners	South Africa	venous blood	Pretoria (столица)	-28,1	25,4	81	0,531	0,469	Lochner C, Kinnear CJ, Hemmings SM, Seller C, Niehaus DJ, Knowles JA, Daniels W, Moolman-Smook JC, Seedat S, Stein DJ. Hoarding in obsessive-compulsive disorder: clinical and genetic correlates. J Clin Psychiatry. 2005 Sep;66(9):1155-60.
Африка	Chagga	Tanzania	mean age of the subjects is 27.91 years. All participants were born in th Mount Kilimanjaro region and both their parents originate from the same area.	Dar-es-Salaam (столица)	-6,5	39,2	45	0,722	0,278	Kenneth K. Kidd et al. "Data unpublished"
Африка	Sandawe	Tanzania	small group of people numbering about 40,000 found in North Central Tanzania	North Central Tanzania, Kondoa (ALFRED)	-5,0	35,5	39	0,679	0,321	Kenneth K. Kidd et al. "Data unpublished"
Африка	hutu and tutsi         (refuge frome Rwanda)	Uganda		Nakivale			452			Kolassa IT, Kolassa S, Ertl V, Papassotiropoulos A, De Quervain DJ. The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism. Biol Psychiatry. 2010 Feb 15;67(4):304-8. Epub 2009 Nov 27.
Африка	algerian	Algeria	Algeria, part of HGDP	Mozabite (Википедия)	32,3	3,4	30	0,580	0,420	?
Африка	egyptian arabs	Egypt	Women, buffy coats	South Egypt, Asyut (статья)	27,1	31,1	175	0,450	0,550	Beverly J. Wolpert, Ph.D., Sania Amr, M.D., Doa’a A. Saleh, M.D., Sameera Ezzat, M.D., Iman Gouda, M.D, Iman Loay, M.D., Tamer Hifnawy, M.D., Mohamed Abdel-Hamid, Ph.D.f, Nabiel N. Mikhail, Ph.D., Min Zhan, Ph.D., Yun-Ling Zheng, M.D., Katherine Squibb, Ph.D.a, Mohamed A. Abdel-Aziz, M.D., Mohamed S. Zaghloul, M.D., Hussein Khaled, M.D., Christopher A. Loffredo, Ph.D. Associations differ by sex for catechol-O-methyltransferase genotypes and bladder cancer risk in South Egypt
Африка	egyptian arabs	Egypt	Men, buffy coats	South Egypt, Asyut (статья)	27,1	31,1	352	0,437	0,564	Beverly J. Wolpert, Ph.D., Sania Amr, M.D., Doa’a A. Saleh, M.D., Sameera Ezzat, M.D., Iman Gouda, M.D, Iman Loay, M.D., Tamer Hifnawy, M.D., Mohamed Abdel-Hamid, Ph.D.f, Nabiel N. Mikhail, Ph.D., Min Zhan, Ph.D., Yun-Ling Zheng, M.D., Katherine Squibb, Ph.D.a, Mohamed A. Abdel-Aziz, M.D., Mohamed S. Zaghloul, M.D., Hussein Khaled, M.D., Christopher A. Loffredo, Ph.D. Associations differ by sex for catechol-O-methyltransferase genotypes and bladder cancer risk in South Egypt
Африка	Ethiopian Jews	Ethiopia	part of the repository of samples on Israeli populations	Tigray&Amhara regions (Википедия)	13,3	39,3	32	0,672	0,328	?
Африка	African American	USA	throughout the USA				90	0,672	0,328	Kenneth K. Kidd et al. "Data unpublished"
Африка	black american	USA	women, cord blood	Minnesota, Minneapolis (статья)			191	0,288	0,712	Chandrasekhar Thota, PhD, Ramkumar Menon, PhD, Melissa J. Wentz, PhD, Stephen J. Fortunato, MD, Jackie Bartlett, MS, Cayce O. Drobek, BS, Sangeeta Nair, MS and Ayman Al-Hendy, MD, PhD. A Single-Nucleotide Polymorphism in the Fetal Catechol-O-methyltransferase Gene is Associated With Spontaneous Preterm Birth in African Americans.Reproductive Sciences 19(2) 135-142
Африка	black american	USA	smokers, peripheral blood	Tennessee, Mississippi, Arkansas (статья)			1366	0,520	0,480	Joke Beuten, Thomas J Payne, Jennie Z Ma and Ming D Li. Significant Association of Catechol-O-Methyltransferase (COMT) Haplotypes with Nicotine Dependence in Male and Female Smokers of Two Ethnic Populations. Neuropsychopharmacology (2006) 31, 675–684
Африка	black american	USA	peripheral blood leukocytes	North Carolina (статья)			263	0,650	0,350	Robert C. Millikan, Garry S. Pittman, Chiu Kit Tse, Eric Duell, Beth Newman, David Savitz, Patricia Moorman, Robert J.Boissy, Duglas A. Bell. Cathol-O-methyltransferase and breast cancer.Carcinogenesis. V 19. N 11. P. 1943-1947.1998
Африка	black american	USA	immortalzed cell lines, some samples frome blood and saliva	New Haven, Farmigton, Belmont, Charlestone (статья)			848	0,720	0,280	Rungnapa Ittiwut, Jennifer B. Listman, Chupong Ittiwut, Joseph F. Cubells, Roger D. Weiss, Kathleen Brady, David Oslin, Lindsay A. Farrer, Henry R. Kranzler, and Joel Gelernter. Association Between Polymorphisms in Catechol-Omethyltransferase (COMT) and Cocaine-Induced Paranoia in European-American and African-American Populations.AMERICAN JOURNAL OF MEDICAL GENETICS PART B
Азия	Ashkenazi Jews	Israel	Israel	central region of Israel (Википедия)	31,5	35,1	73	0,514	0,486	Kenneth K. Kidd et al. "Data unpublished"
Азия	Israel-Bedouin	Israel	part of HGDP	Negev region, southern Israel (ALFRED)	35,0	34,9	48	0,590	0,410	?
Азия	Israel-Druze	Israel	Moslem community	Northern Israel (ALFRED)	32,5	35,2	74	0,615	0,385	Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999)
Азия	jews (all groups)	Israel	10 ml fresh blood	Tirat Carmel (статья)	32,5	34,6	171	0,540	0,460	Michael Poyurovsky, Elena Michaelovsky, Amos Frisch, Gabriela Knoll, Ilan Amir, Boris Finkel, Feodor Buniak, Haggai Hermeshd, Ronit Weizman. COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: A case–control study. Neuroscience Letters 389 (2005) 21–24
Азия	jews (all groups)	Israel	frozen blood	Beersheva (статья)	31,2	34,5	415	0,547	0,453	Moshe Kotler, Peretz Barak, Hagit Cohen, Ilya E. Averbuch, Alexander Grinshpoon, Inga Gritsenko, Lubov Nemanov, Richard P. Ebstein Homicidal Behavior in Schizophrenia Associated цith a Genetic Polymorphism Determining Low Catechol O-Methyltransferase (COMT) Activity. American Journal of Medical Genetics (Neuropsychiatric Genetics) 88: 628–633 (1999)
Азия	jews (ashkenazi)	Israel	frozen blood, *	Beersheva (статья)	31,2	34,5	257	0,547	0,453	Moshe Kotler, Peretz Barak, Hagit Cohen, Ilya E. Averbuch, Alexander Grinshpoon, Inga Gritsenko, Lubov Nemanov, Richard P. Ebstein Homicidal Behavior in Schizophrenia Associated цith a Genetic Polymorphism Determining Low Catechol O-Methyltransferase (COMT) Activity. American Journal of Medical Genetics (Neuropsychiatric Genetics) 88:628–633 (1999)
Азия	Palestinian	Israel	part of HGDP	central region of Israel (ALFRED)	31,5	35,1	51	0,430	0,570	?
Азия	palestinian arabs	Israel	?	Northern Part, Nazareth (статья)	32,4	35,2	77	0,435	0,565	I. Kremer, M. Pinto, I. Murad, M. Muhaheed, I. Bannoura, D.J. Muller, T.G. Schulze, A. Reshef, M. Blanaru, S. Gathas, R. Goichman, M. Rietschel, M. Dobrusin, R. Bachner-Melman, L. Nemanov, R.H. Belmaker, W. Maier, and R.P. Ebstein. Family-Based and Case–Control Study of Catechol-O Methyltransferase in Schizophrenia Among Palestinian Arabs