Заведующий лабораторией эволюционной геномики
Рогаев Евгений Иванович, д.б.н.,профессор
Руководитель отдела геномики и генетики человека ИОГен РАН
профессор факультета биоинженерии и биоинформатики МГУ
Профессор Психиатрии Медицинской Школы Университета Массачусеттса
Основные научные достижения
- Обнаружение семейств гипервариабельных элементов генома человека и практическое внедрение метода индивидуальной ДНК-идентификации.
- Обнаружение генов, нарушения в которых ответственны за ряд наследственных болезней человека, в том числе генов болезни Альцгеймера.
- Идентификация гена и молекулярного механизма, ответственного за регенерацию и рост волос.
- Картирование специфичных для человека эпигенетических сайтов, регулирующих активность генов в нейронах мозга.
- ДНК-исследования палеонтологических и “исторических” образцов.
Научное признание
- Государственная Премия Российской Федерации, 1996 г.
- Премия им Баева, 1997 г.
- Международный Ученый Научного Института им. Ховарда Хьюза (Howard Hughes Medical Institute International Research Scholar Award), 1995 г.
- Альцгеймеровской Ассоциации фонда им. Темпла (Discovery Award of LLL Temple Foundation, Alzheimer’s Association) , 2003 г.
- Общества по Исследованию шизофрениии аффективных расстройств (Distinguished Investigator NARSAD Award, National Alliance of Research in Schizophrenia and Affective Disorders), 2008 г.
- Член Европейской Академии (Academia Europaea), с 2010 г.
Публикации
Список публикаций в Google Scholar
Избранные публикации:
Leonid L. Moroz, Kevin M. Kocot, Mathew R. Citarella, Sohn Dosung, Tigran P. Norekian, Inna S. Povolotskaya, Anastasia P. Grigorenko, Christopher Dailey, Eugene Berezikov, Katherine M. Buckley, Andrey Ptitsyn, Denis Reshetov, Krishanu Mukherjee, Tatiana P. Moroz, Yelena Bobkova, Fahong Yu, Vladimir V. Kapitonov, Jerzy Jurka, Yuri V. Bobkov, Joshua J. Swore, David O. Girardo, Alexander Fodor, Fedor Gusev, Rachel Sanford, Rebecca Bruders, Ellen Kittler, Claudia E. Mills, Jonathan P. Rast, Romain Derelle, Victor V. Solovyev, Fyodor A. Kondrashov, Billie J. Swalla, Jonathan V. Sweedler, Evgeny I. Rogaev, Kenneth M. Halanych & Andrea B. Kohn The ctenophore genome and the evolutionary origins of neural systems // Nature (2014) doi:10.1038/nature13400
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing // Nature. 2000 Sep 7;407(6800):48-54.
Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene // Nature. 1995 Aug 31;376(6543):775-8.
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease // Nature. 1995 Jun 29;375(6534):754-60.
Rogaev EI, Grigorenko AP, Faskhutdinova G, Kittler EL, Moliaka YK. Genotype analysis identifies the cause of the "royal disease" // Science. 2009 Nov 6;326(5954):817.
Kazantseva A, Goltsov A, Zinchenko R, Grigorenko AP, Abrukova AV, Moliaka YK, Kirillov AG, Guo Z, Lyle S, Ginter EK, Rogaev EI. Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH // Science. 2006 Nov 10;314(5801):982-5.
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St George-Hyslop P, McLachlan DC, Tsuda T, Rogaev E, Karlinsky H, Lippa CF, Pollen D. Alzheimer's disease and possible gene interaction // Science. 1994 Jan 28;263(5146):537
Rogaev EI, Zinchenko RA, Dvoryachikov G, Sherbatich T, Ginter EK. Total hypotrichosis: genetic form of alopecia not linked to hairless gene // Lancet. 1999 Sep 25;354(9184):1097-8.
Korovaitseva GI, Bukina A, Farrer LA, Rogaev EI. Presenilin polymorphisms in Alzheimer's disease // Lancet. 1997 Sep 27;350(9082): 959.
Sorbi S, Nacmias B, Forleo P, Piacentini S, Sherrington R, Rogaev E, St George Hyslop P, Amaducci L. Missense mutation of S182 gene in Italian families with early-onset Alzheimer's disease // Lancet. 1995 Aug 12;346(8972):439-40
Rogaev EI, Grigorenko AP, Moliaka YK, Faskhutdinova G, Goltsov A, Lahti A, Hildebrandt C, Kittler EL, Morozova I. Genomic identification in the historical case of the Nicholas II royal family // Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5258-63.
Chen F, Wollmer MA, Hoerndli F, Münch G, Kuhla B, Rogaev EI, Tsolaki M, Papassotiropoulos A, Götz J. Role for glyoxalase I in Alzheimer's disease. // Proc Natl Acad Sci U S A. 2004 May 18;101(20):7687-92.
Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouellette G, Fortier I, Raelson J, Sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P, Aerssens J, Konings F, Luyten W, Macciardi F, Sham PC, Straub RE, Weinberger DR, Cohen N, Cohen D. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. // Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13675-80.
Trower MK, Orton SM, Purvis IJ, Sanseau P, Riley J, Christodoulou C, Burt D, See CG, Elgar G, Sherrington R, Rogaev EI, St George-Hyslop P, Brenner S, Dykes CW. Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus) // Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1366-9
Публикации 1986-2010
1: Underhill PA, Myres NM, Rootsi S, Metspalu M, Zhivotovsky LA, King RJ, Lin AA,
Chow CE, Semino O, Battaglia V, Kutuev I, Järve M, Chaubey G, Ayub Q, Mohyuddin
A, Mehdi SQ, Sengupta S, Rogaev EI, Khusnutdinova EK, Pshenichnov A, Balanovsky
O, Balanovska E, Jeran N, Augustin DH, Baldovic M, Herrera RJ, Thangaraj K, Singh
V, Singh L, Majumder P, Rudan P, Primorac D, Villems R, Kivisild T. Separating
the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup
R1a. Eur J Hum Genet. 2010 Sep;18(9):1074. PubMed PMID: 20725086.
2: Underhill PA, Myres NM, Rootsi S, Metspalu M, Zhivotovsky LA, King RJ, Lin AA,
Chow CE, Semino O, Battaglia V, Kutuev I, Järve M, Chaubey G, Ayub Q, Mohyuddin
A, Mehdi SQ, Sengupta S, Rogaev EI, Khusnutdinova EK, Pshenichnov A, Balanovsky
O, Balanovska E, Jeran N, Augustin DH, Baldovic M, Herrera RJ, Thangaraj K, Singh
V, Singh L, Majumder P, Rudan P, Primorac D, Villems R, Kivisild T. Separating
the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup
R1a. Eur J Hum Genet. 2010 Apr;18(4):479-84. Epub 2009 Nov 4. PubMed PMID:
19888303.
3: Rogaev EI, Grigorenko AP, Faskhutdinova G, Kittler EL, Moliaka YK. Genotype
analysis identifies the cause of the "royal disease". Science. 2009 Nov
6;326(5954):817. Epub 2009 Oct 8. PubMed PMID: 19815722.
4: Järve M, Zhivotovsky LA, Rootsi S, Help H, Rogaev EI, Khusnutdinova EK,
Kivisild T, Sanchez JJ. Decreased rate of evolution in Y chromosome STR loci of
increased size of the repeat unit. PLoS One. 2009 Sep 30;4(9):e7276. PubMed PMID:
19789645; PubMed Central PMCID: PMC2748704.
5: Rogaev EI, Grigorenko AP, Moliaka YK, Faskhutdinova G, Goltsov A, Lahti A,
Hildebrandt C, Kittler EL, Morozova I. Genomic identification in the historical
case of the Nicholas II royal family. Proc Natl Acad Sci U S A. 2009 Mar
31;106(13):5258-63. Epub 2009 Feb 27. PubMed PMID: 19251637; PubMed Central
PMCID: PMC2664067.
6: Rogaev EI, Borinskaia SA, Islamgulov DV, Grigorenko AP. [Human microRNA in
norm and pathology]. Mol Biol (Mosk). 2008 Sep-Oct;42(5):751-64. Review. Russian.
PubMed PMID: 18988525.
7: Ponomareva NV, Korovaitseva GI, Rogaev EI. EEG alterations in non-demented
individuals related to apolipoprotein E genotype and to risk of Alzheimer
disease. Neurobiol Aging. 2008 Jun;29(6):819-27. Epub 2007 Feb 12. PubMed PMID:
17293007.
8: Borinskaia SA, Kal'ina NR, Sanina ED, Kozhekbaeva ZhM, Gupalo EIu, Garmash IV,
Ogurtsov PP, Parshukova ON, Boĭko SG, Veselovskiĭ EM, Vershubskaia GG, Kozlov AI,
Rogaev EI, Iankovskiĭ NK. [Polymorphism of the apolipoprotein E gene (APOE) in
the populations of Russia and neighboring countries]. Genetika. 2007
Oct;43(10):1434-40. Russian. PubMed PMID: 18069348.
9: Plotnikova OV, Kondrashov FA, Vlasov PK, Grigorenko AP, Ginter EK, Rogaev EI.
Conversion and compensatory evolution of the gamma-crystallin genes and
identification of a cataractogenic mutation that reverses the sequence of the
human CRYGD gene to an ancestral state. Am J Hum Genet. 2007 Jul;81(1):32-43.
Epub 2007 May 16. PubMed PMID: 17564961; PubMed Central PMCID: PMC1950927.
10: Burmistrova OA, Goltsov AY, Abramova LI, Kaleda VG, Orlova VA, Rogaev EI.
MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11).
Biochemistry (Mosc). 2007 May;72(5):578-82. PubMed PMID: 17573714.
11: Grigorenko AP, Rogaev EI. [Molecular basics of Alzheimer's disease]. Mol Biol
(Mosk). 2007 Mar-Apr;41(2):331-45. Review. Russian. PubMed PMID: 17514900.
12: Kazantseva A, Goltsov A, Zinchenko R, Grigorenko AP, Abrukova AV, Moliaka YK,
Kirillov AG, Guo Z, Lyle S, Ginter EK, Rogaev EI. Human hair growth deficiency is
linked to a genetic defect in the phospholipase gene LIPH. Science. 2006 Nov
10;314(5801):982-5. PubMed PMID: 17095700.
13: Goltsov AY, Loseva JG, Andreeva TV, Grigorenko AP, Abramova LI, Kaleda VG,
Orlova VA, Moliaka YK, Rogaev EI. Polymorphism in the 5'-promoter region of
serine racemase gene in schizophrenia. Mol Psychiatry. 2006 Apr;11(4):325-6.
PubMed PMID: 16446740.
14: Rogaev EI, Moliaka YK, Malyarchuk BA, Kondrashov FA, Derenko MV, Chumakov I,
Grigorenko AP. Complete mitochondrial genome and phylogeny of Pleistocene mammoth
Mammuthus primigenius. PLoS Biol. 2006 Mar;4(3):e73. Epub 2006 Feb 7. PubMed
PMID: 16448217; PubMed Central PMCID: PMC1360101.
15: Rogaev EI. Small RNAs in human brain development and disorders. Biochemistry
(Mosc). 2005 Dec;70(12):1404-7. PubMed PMID: 16417465.
16: Papassotiropoulos A, Lambert JC, Wavrant-De Vrièze F, Wollmer MA, von der
Kammer H, Streffer JR, Maddalena A, Huynh KD, Wolleb S, Lutjohann D, Schneider B,
Thal DR, Grimaldi LM, Tsolaki M, Kapaki E, Ravid R, Konietzko U, Hegi T, Pasch T,
Jung H, Braak H, Amouyel P, Rogaev EI, Hardy J, Hock C, Nitsch RM. Cholesterol
25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic
Alzheimer's disease. Neurodegener Dis. 2005;2(5):233-41. PubMed PMID: 16909003.
17: Golimbet VE, Lebedeva IS, Gritsenko IK, Korovaĭtseva GI, Alfimova MV,
Lezheĭko TV, Abramova LI, Kaleda VG, Ebshteĭn RP, Rogaev EI. [A study of some
genes related to serotoninergic and dopaminergic systems and auditory
evoked-potentials (P300) in patients with schizophrenia and spectrum disorders
and their first-degree relatives]. Zh Nevrol Psikhiatr Im S S Korsakova.
2005;105(10):35-41. Russian. PubMed PMID: 16281377.
18: Grigorenko AP, Moliaka YK, Soto MC, Mello CC, Rogaev EI. The Caenorhabditis
elegans IMPAS gene, imp-2, is essential for development and is functionally
distinct from related presenilins. Proc Natl Acad Sci U S A. 2004 Oct
12;101(41):14955-60. Epub 2004 Oct 6. PubMed PMID: 15469912; PubMed Central
PMCID: PMC522053.
19: Chen F, Wollmer MA, Hoerndli F, Münch G, Kuhla B, Rogaev EI, Tsolaki M,
Papassotiropoulos A, Götz J. Role for glyoxalase I in Alzheimer's disease. Proc
Natl Acad Sci U S A. 2004 May 18;101(20):7687-92. Epub 2004 May 5. PubMed PMID:
15128939; PubMed Central PMCID: PMC419667.
20: Golimbet VE, Alfimova MV, Shchebatykh TV, Abramova LI, Kaleda VG, Rogaev EI.
Serotonin transporter polymorphism and depressive-related symptoms in
schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):1-7.
PubMed PMID: 15048639.
21: Moliaka YK, Grigorenko A, Madera D, Rogaev EI. Impas 1 possesses
endoproteolytic activity against multipass membrane protein substrate cleaving
the presenilin 1 holoprotein. FEBS Lett. 2004 Jan 16;557(1-3):185-92. PubMed
PMID: 14741365.
22: Bobrysheva IV, Grigorenko AP, Novosadova EV, Kal'ina NR, Arsenyeva EL,
Grivennikov IA, Tarantul VZ, Rogaev EI. Effects of human presenilin 1 isoforms on
proliferation and survival of rat pheochromocytoma cell line PC12. Biochemistry
(Mosc). 2003 Jun;68(6):611-7. PubMed PMID: 12943504.
23: Golimbet VE, Alfimova MV, Shcherbatykh TV, Rogaev EI. [Gene insertion and
deletion polymorphism in the serotonin transporter gene and personality traits
measured by MMPI]. Genetika. 2003 Apr;39(4):534-9. Russian. PubMed PMID:
12760255.
24: Golimbet VE, Alfimova MV, Shcherbatikh T, Kaleda VG, Abramova LI, Rogaev EI.
Serotonin transporter gene polymorphism and schizoid personality traits in the
patients with psychosis and psychiatrically well subjects. World J Biol
Psychiatry. 2003 Jan;4(1):25-9. PubMed PMID: 12582974.
25: Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI. Novel class of
polytopic proteins with domains associated with putative protease activity.
Biochemistry (Mosc). 2002 Jul;67(7):826-35. PubMed PMID: 12139484.
26: Golimbet VE, Alfimova MV, Shcherbatykh TV, Rogaev EI. [Allele polymorphism of
the serotonin transporter gene and clinical heterogeneity of depressive
disorders]. Genetika. 2002 May;38(5):671-7. Russian. PubMed PMID: 12068552.
27: Maliarchuk BA, Derenko MV, Denisova GA, Nassiri MR, Rogaev EI. [Mitochondrial
DNA polymorphism in populations of the Caspian region and southeastern Europe].
Genetika. 2002 Apr;38(4):534-8. Russian. PubMed PMID: 12018172.
28: Iatsyshina SB, Moliaka IuK, Karpova SK, Chekhranova MK, Popova IuP, Grigorian
ON, Pankov IuA, Rogaev EI. [Study of the association between constitutional
exogenous obesity and polymorphism of the apolipoprotein B gene]. Genetika. 2002
Feb;38(2):285-8. Russian. PubMed PMID: 11898622.
29: Pankov IuA, Iatsyshina SB, Karpova SK, Chekhranova MK, Popova IuP, Grigorian
ON, Rogaev EI. [Screening of mutations in genes of pro-opiomelanocortin in
patients with constitutional exogenous obesity]. Vopr Med Khim. 2002
Jan-Feb;48(1):121-30. Russian. PubMed PMID: 12068494.
30: Maliarchuk BA, Denisova GA, Derenko MV, Rogaev EI, Vlasenko LV, Zhukova SG.
[Variability in mitochondrial DNA in Russian inhabitants from Krasnodar Krai,
Belgorod and the lower Novgorod region]. Genetika. 2001 Oct;37(10):1411-6.
Russian. PubMed PMID: 11761619.
31: Nicolaou M, Song YQ, Sato CA, Orlacchio A, Kawarai T, Medeiros H, Liang Y,
Sorbi S, Richard E, Rogaev EI, Moliaka Y, Bruni AC, Jorge R, Percy M, Duara R,
Farrer LA, St Georg-Hyslop P, Rogaeva EA. Mutations in the open reading frame of
the beta-site APP cleaving enzyme (BACE) locus are not a common cause of
Alzheimer's disease. Neurogenetics. 2001 Oct;3(4):203-6. PubMed PMID: 11714100.
32: Rogaeva EA, Fafel KC, Song YQ, Medeiros H, Sato C, Liang Y, Richard E, Rogaev
EI, Frommelt P, Sadovnick AD, Meschino W, Rockwood K, Boss MA, Mayeux R, St
George-Hyslop P. Screening for PS1 mutations in a referral-based series of AD
cases: 21 novel mutations. Neurology. 2001 Aug 28;57(4):621-5. PubMed PMID:
11524469.
33: Ginter EK, Kirillov AG, Rogaev EI. [Autosomal-dominant osteopetrosis in
Chuvashiya]. Genetika. 2001 Aug;37(8):1152-5. Russian. PubMed PMID: 11642116.
34: Golimbet VE, Alfimova VM, Shcherbatykh TV, Abramova LI, Kaleda VG, Rogaev EI.
[Insertion-deletion polymorphism of the serotonin carrier gene and evaluation of
neurotism as a temperament trait in patients with affective disorders and
mentally healthy people]. Mol Biol (Mosk). 2001 May-Jun;35(3):397-400. Russian.
PubMed PMID: 11443919.
35: Korovaĭtseva GI, Shcherbatykh TV, Selezneva NV, Gavrilova SI, Golimbet VE,
Voskresenskaia NI, Rogaev EI. [Genetic association between the apolipoprotein E
(ApoE) gene alleles and various forms of Alzheimer's disease]. Genetika. 2001
Apr;37(4):529-35. Russian. PubMed PMID: 11421127.
36: Shcherbatykh TV, Kiryanov SA, Korovaitseva GI, Selezneva ND, Voskresenskaya
NI, Golimbet VE, Farrer L, Gavrilova SI, Rogaev EI. The angiotensin-converting
enzyme gene as a possible risk or protective factor in Alzheimer's disease.
Neurosci Behav Physiol. 2001 Mar-Apr;31(2):179-81. PubMed PMID: 11388371.
37: Lukiw WJ, Gordon WC, Rogaev EI, Thompson H, Bazan NG. Presenilin-2 (PS2)
expression up-regulation in a model of retinopathy of prematurity and
pathoangiogenesis. Neuroreport. 2001 Jan 22;12(1):53-7. PubMed PMID: 11201091.
38: Golimbet VE, Shcherbatykh TV, Abramova LI, Kaleda VG, Oleĭchik IV, Orlova VA,
Rogaev EI. [Serotonin transporter gene polymorphism in families with
schizophrenia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2001;101(10):40-1. Russian.
PubMed PMID: 11712269.
39: Golimbet VE, Mitiushina NG, Shcherbatykh TV, Aksenova MG, Abramova LI, Kaleda
VG, Nosikov VV, Iurov IuB, Rogaev EI. [Molecular genetic polymorphism of the
genes of neurotransmitter systems in schizophrenics with early manifestation of
the disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 2001;101(4):48-50. Russian.
PubMed PMID: 11490436.
40: Farrer LA, Sherbatich T, Keryanov SA, Korovaitseva GI, Rogaeva EA, Petruk S,
Premkumar S, Moliaka Y, Song YQ, Pei Y, Sato C, Selezneva ND, Voskresenskaya S,
Golimbet V, Sorbi S, Duara R, Gavrilova S, St George-Hyslop PH, Rogaev EI.
Association between angiotensin-converting enzyme and Alzheimer disease. Arch
Neurol. 2000 Feb;57(2):210-4. PubMed PMID: 10681079.
41: Rogaev EI. [Genetic factors and a polygenic model of Alzheimer's disease].
Genetika. 1999 Nov;35(11):1558-71. Review. Russian. PubMed PMID: 10624576.
42: Rogaev EI, Zinchenko RA, Dvoryachikov G, Sherbatich T, Ginter EK. Total
hypotrichosis: genetic form of alopecia not linked to hairless gene. Lancet. 1999
Sep 25;354(9184):1097-8. PubMed PMID: 10509509.
43: Korovaitseva GI, Premkumar S, Grigorenko A, Molyaka Y, Galimbet V, Selezneva
N, Gavrilova SI, Farrer LA, Rogaev EI. Alpha-2 macroglobulin gene in early- and
late-onset Alzheimer disease. Neurosci Lett. 1999 Aug 20;271(2):129-31. PubMed
PMID: 10477119.
44: Rogaev EI. [Genetic basis for Alzheimer's disease and other dementias and
prospects of molecular diagnosis]. Vestn Ross Akad Med Nauk. 1999;(1):33-9.
Review. Russian. PubMed PMID: 10078061.
45: Shcherbatykh TV, Kir'ianov SA, Korovaĭtsev GI, Selezneva ND, Voskresenskaia
NI, Golimbet VE, Farrr L, Gavrilova SI, Rogaev EI. [Angiotensin-converting enzyme
gene as a possible risk factor or protective factor in Alzheimer's disease]. Zh
Nevrol Psikhiatr Im S S Korsakova. 1999;99(9):51-2. Russian. PubMed PMID:
10533256.
46: Solov'ev IV, Iurov IuB, Vorsanova SG, Marcais B, Rogaev EI, Kapanadze BI,
Brodianskiĭ VM, Iankovskiĭ NK, Roizes G. [Study of alpha-satellite DNA in cosmid
libraries, specific for chromosomes 13, 21, and 22, using fluorescence in situ
hybridization]. Genetika. 1998 Nov;34(11):1470-9. Russian. PubMed PMID: 10096024.
47: Rogaev EI. [Presenilins: detection and characterization of Alzheimer's
disease genes]. Mol Biol (Mosk). 1998 Jan-Feb;32(1):71-83. Review. Russian.
PubMed PMID: 9566253.
48: Korovaitseva GI, Bukina A, Farrer LA, Rogaev EI. Presenilin polymorphisms in
Alzheimer's disease. Lancet. 1997 Sep 27;350(9082):959. PubMed PMID: 9314893.
49: Kir'ianov SA, Rogaev EI. [Rapid isolation of CpG-islands by PCR-amplification
of genomic DNA fragments using a "CpG-enriched" primer]. Genetika. 1997
Jul;33(7):891-8. Russian. PubMed PMID: 9378285.
50: Moliaka IuK, Ovchinnikov IV, Shlenskiĭ AB, Korovaĭtseva GI, Rogaev EI. [DNA
genotyposcoy in determining paternity: use of hybridized probes]. Genetika. 1997
Jun;33(6):831-5. Russian. PubMed PMID: 9289421.
51: Rogaev EI, Sherrington R, Wu C, Levesque G, Liang Y, Rogaeva EA, Ikeda M,
Holman K, Lin C, Lukiw WJ, de Jong PJ, Fraser PE, Rommens JM, St George-Hyslop P.
Analysis of the 5' sequence, genomic structure, and alternative splicing of the
presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease.
Genomics. 1997 Mar 15;40(3):415-24. PubMed PMID: 9073509.
52: Rogaev EI, Ovchinnikov IV, Dzhorzh-Khislop P, Rogaeva EA. [Comparison of
mitochondrial DNA sequences of T.N. Kulikovskiĭ-Romanov, the nephew of Tsar
Nikolaĭ II Romanov, with DNA from the putative remains of the Tsar]. Genetika.
1996 Dec;32(12):1690-2. Russian. PubMed PMID: 9102362.
53: Sherrington R, Froelich S, Sorbi S, Campion D, Chi H, Rogaeva EA, Levesque G,
Rogaev EI, Lin C, Liang Y, Ikeda M, Mar L, Brice A, Agid Y, Percy ME,
Clerget-Darpoux F, Piacentini S, Marcon G, Nacmias B, Amaducci L, Frebourg T,
Lannfelt L, Rommens JM, St George-Hyslop PH. Alzheimer's disease associated with
mutations in presenilin 2 is rare and variably penetrant. Hum Mol Genet. 1996
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54: Igarashi S, Takiyama Y, Cancel G, Rogaeva EA, Sasaki H, Wakisaka A, Zhou YX,
Takano H, Endo K, Sanpei K, Oyake M, Tanaka H, Stevanin G, Abbas N, Dürr A,
Rogaev EI, Sherrington R, Tsuda T, Ikeda M, Cassa E, Nishizawa M, Benomar A,
Julien J, Weissenbach J, Wang GX, Agid Y, St George-Hyslop PH, Brice A, Tsuji S.
Intergenerational instability of the CAG repeat of the gene for Machado-Joseph
disease (MJD1) is affected by the genotype of the normal chromosome: implications
for the molecular mechanisms of the instability of the CAG repeat. Hum Mol Genet.
1996 Jul;5(7):923-32. PubMed PMID: 8817326.
55: Rogaev EI, Rogaeva EA, Korovaitseva GI, Farrer LA, Petrin AN, Keryanov SA,
Turaeva S, Chumakov I, St George-Hyslop P, Ginter EK. Linkage of polymorphic
congenital cataract to the gamma-crystallin gene locus on human chromosome
2q33-35. Hum Mol Genet. 1996 May;5(5):699-703. PubMed PMID: 8733140.
56: Trower MK, Orton SM, Purvis IJ, Sanseau P, Riley J, Christodoulou C, Burt D,
See CG, Elgar G, Sherrington R, Rogaev EI, St George-Hyslop P, Brenner S, Dykes
CW. Conservation of synteny between the genome of the pufferfish (Fugu rubripes)
and the region on human chromosome 14 (14q24.3) associated with familial
Alzheimer disease (AD3 locus). Proc Natl Acad Sci U S A. 1996 Feb
20;93(4):1366-9. PubMed PMID: 8643637; PubMed Central PMCID: PMC39943.
57: Golimbet VE, Ovchinnikov IV, Voskresenskaia NI, Iurov IuB, Rogaev EI,
Doronina OA, Maksunova IV. [The search for a mutation in the gene coding the
beta-amyloid protein precursor gene in patients with Alzheimer-type dementias].
Zh Nevrol Psikhiatr Im S S Korsakova. 1996;96(1):75-8. Russian. PubMed PMID:
8677726.
58: Tsuda T, Chi H, Liang Y, Rogaeva EA, Sherrington R, Levesque G, Ikeda M,
Rogaev EI, Pollen D, Freedman M, et al. Failure to detect missense mutations in
the S182 gene in a series of late-onset Alzheimer's disease cases. Neurosci Lett.
1995 Dec 8;201(2):188-90. PubMed PMID: 8848249.
59: Allsopp RC, Chang E, Kashefi-Aazam M, Rogaev EI, Piatyszek MA, Shay JW,
Harley CB. Telomere shortening is associated with cell division in vitro and in
vivo. Exp Cell Res. 1995 Sep;220(1):194-200. PubMed PMID: 7664836.
60: Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H,
Lin C, Holman K, Tsuda T, et al. Familial Alzheimer's disease in kindreds with
missense mutations in a gene on chromosome 1 related to the Alzheimer's disease
type 3 gene. Nature. 1995 Aug 31;376(6543):775-8. PubMed PMID: 7651536.
61: Takiyama Y, Igarashi S, Rogaeva EA, Endo K, Rogaev EI, Tanaka H, Sherrington
R, Sanpei K, Liang Y, Saito M, et al. Evidence for inter-generational instability
in the CAG repeat in the MJD1 gene and for conserved haplotypes at flanking
markers amongst Japanese and Caucasian subjects with Machado-Joseph disease. Hum
Mol Genet. 1995 Jul;4(7):1137-46. PubMed PMID: 8528200.
62: Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H,
Lin C, Li G, Holman K, et al. Cloning of a gene bearing missense mutations in
early-onset familial Alzheimer's disease. Nature. 1995 Jun 29;375(6534):754-60.
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63: Rogaev EI, Rogaeva EA, Dzhordzh-Khislop P. [Direct detection of loci with
pathologic trinucleotide repeats in diseases with anticipation]. Genetika. 1995
Apr;31(4):578-82. Russian. PubMed PMID: 7607444.
64: Rogaev EI, Lukiw WJ, Lavrushina O, Rogaeva EA, St George-Hyslop PH. The
upstream promoter of the beta-amyloid precursor protein gene (APP) shows
differential patterns of methylation in human brain. Genomics. 1994 Jul
15;22(2):340-7. PubMed PMID: 7528717.
65: St George-Hyslop P, Rogaeva E, Huterer J, Tsuda T, Santos J, Haines JL,
Schlumpf K, Rogaev EI, Liang Y, McLachlan DR, et al. Machado-Joseph disease in
pedigrees of Azorean descent is linked to chromosome 14. Am J Hum Genet. 1994
Jul;55(1):120-5. PubMed PMID: 8023841; PubMed Central PMCID: PMC1918207.
66: Lukiw WJ, Rogaev EI, Wong L, Vaula G, McLachlan DR, St George Hyslop P.
Protein-DNA interactions in the promoter region of the amyloid precursor protein
(APP) gene in human neocortex. Brain Res Mol Brain Res. 1994 Mar;22(1-4):121-31.
PubMed PMID: 8015372.
67: Rogaev EI, Rogaeva EA, Ginter EK, Korovaĭtseva GI, Farrer L, Shlenskiĭ AB,
Prytkov AN, St George-Hyslop P, Mordovtsev VN. [Mapping the gene for palmoplantar
hyperkeratosis (thylosis) to chromosome 17 in the 17q12-q24 region]. Genetika.
1994 Mar;30(3):326-9. Russian. PubMed PMID: 7514555.
68: Iakimov MM, Rogozhin IS, Kal'deron E, Matveeva LN, Karavaĭtseva GI,
Bezborodov AM, Rogaev EI. [Tn5-mutagenesis of the styrene-degrading strain
Pseudomonas sp. Y2. Analysis of transformation products and DNA-scopy of the
mutants obtained]. Prikl Biokhim Mikrobiol. 1994 Jan-Feb;30(1):55-63. Russian.
PubMed PMID: 8146112.
69: Rogaev EI, Lukiw WJ, Vaula G, Haines JL, Rogaeva EA, Tsuda T, Alexandrova N,
Liang Y, Mortilla M, Amaducci L, et al. Analysis of the c-FOS gene on chromosome
14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's
disease. Neurology. 1993 Nov;43(11):2275-9. PubMed PMID: 8232942.
70: Rogaev EI, Rogaeva EA, Ginter EK, Korovaitseva GI, Farrer LA, Shlensky AB,
Pritkov AN, Mordovtsev VN, St George-Hyslop PH. Identification of the genetic
locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and
keratin type I genes. Nat Genet. 1993 Oct;5(2):158-62. PubMed PMID: 7504553.
71: Rogaev EI, Korovaĭtseva GI, Ginter EK, Prytkov AN, Maksudova KhA. [Mapping of
the dominant gene of hyperkeratosis palmaris et plantaris in man]. Genetika. 1993
Jul;29(7):1180-5. Russian. PubMed PMID: 8370514.
72: Bochkov NP, Rogaev EI, Moliaka IuK, Shlenskiĭ AB, Asanov AIu. [Detection of
gamete mutations in the hypervariable region of human DNA for genetic
monitoring]. Dokl Akad Nauk. 1993 Apr;329(6):785-6. Russian. PubMed PMID:
8508130.
73: Ginter EK, Rogaev EI, Korovaĭtseva GI, Turaeva ShM, Petrin AN, Spitsyn VA,
Tarlycheva LV. [Further analysis of location of the gene for inborn dominant
Nochurli cataract]. Genetika. 1993 Apr;29(4):670-4. Russian. PubMed PMID:
8354473.
74: Rogaev EI, Keryanov SA. Unusual variability of the complex dinucleotide
repeat block at the SPN locus. Hum Mol Genet. 1992 Nov;1(8):657. PubMed PMID:
1301183.
75: Rogaev EI, Keryanov SA, Malyako YK. Dinucleotide repeat polymorphisms at the
P1, HBE1 and MYH7 loci. Hum Mol Genet. 1992 Jul;1(4):285. PubMed PMID: 1363870.
76: Rogaev EI, Syrokvasheva EIu, Pimenov MG, Stegnova TV. [Human genotyposcopy:
the identification of the species, sex and individual by DNA genetic imprints in
a case connected with a murder attempt]. Sud Med Ekspert. 1992
Jan-Mar;35(1):10-4. Russian. PubMed PMID: 1589883.
77: Rogaev EI, Iurov IuB, Iakovlev AG. [Molecular genetics of the human brain].
Vestn Ross Akad Med Nauk. 1992;(8):11-6. Review. Russian. PubMed PMID: 1282409.
78: Ginter EK, Petrin AN, Spitsyn VA, Rogaev EI. [An attempt to locate the gene
for congenital cataracts using linkage analysis]. Genetika. 1991
Oct;27(10):1840-9. Russian. PubMed PMID: 1778455.
79: Rogaev EI, Shlenskii AB, Spoode AYa. Individual-specific patterns of human
variable genomic regions detected by a DNA probe from the HIV-1 env gene. Biomed
Sci. 1991;2(3):311-3. PubMed PMID: 1751767.
80: Rogaev EI, Shlenskiĭ AB. [DNA probe containing elements of the gene of
surface glycoprotein of HIV-1 virus, an effective molecular marker in
genotyposcopy of man]. Biull Eksp Biol Med. 1990 Dec;110(12):646-7. Russian.
PubMed PMID: 2083371.
81: Nefedov MD, Gar'kavtsev IV, Rogaev EI. [Analysis of the association of
inherited predisposition to breast cancer with c-Ha-ras-1 oncogene alleles].
Genetika. 1990 Dec;26(12):2226-31. Russian. PubMed PMID: 2086347.
82: Rogaev EI, Shlenskiĭ AV. [The test for the genomic DNA of bacteriophage FD
103 detects hypervariable regions in the human genome]. Biull Eksp Biol Med. 1990
Nov;110(11):525. Russian. PubMed PMID: 2083338.
83: Rogaev EI, Iurov IuB. [Interindividual hyperpolymorphism of autosomal
satellites III of human DNA]. Genetika. 1990 Aug;26(8):1532-5. Russian. PubMed
PMID: 1979546.
84: Rogaev EI. Simple human DNA-repeats associated with genomic hypervariability,
flanking the genomic retroposons and similar to retroviral sites. Nucleic Acids
Res. 1990 Apr 11;18(7):1879-85. PubMed PMID: 2159624; PubMed Central PMCID:
PMC330609.
85: Rogaev EI, Shlensky AB. The genomic DNA phi Fd103 probe is sensitive marker
for detection of human hypervariable genomic regions. Nucleic Acids Res. 1990 Feb
25;18(4):1081. PubMed PMID: 2179868; PubMed Central PMCID: PMC330398.
86: Rogaev EI, Vetchinkina AA, Iurov IuB. Species specific variant of human
centromeric DNA repeats: localization on chromosome 18 and recent amplification
in human ancestral line]. Mol Gen Mikrobiol Virusol. 1989 Apr;(4):10-4. Russian.
PubMed PMID: 2747696.
87: Rogaev EI. Two novel human DNA tandem repeat families from the hypervariable
DNA probe homologous to human apolipoprotein CII-gene intron and D. virilis
satellite. Nucleic Acids Res. 1989 Feb 11;17(3):1246. PubMed PMID: 2922263;
PubMed Central PMCID: PMC331743.
88: Rogaev EI. [The structure of genome region containing unstable elements of
human DNA]. Dokl Akad Nauk SSSR. 1988 Sep-Oct;302(1):234-8. Russian. PubMed PMID:
2906584.
89: Rogaev EI, Shapiro IuA. [High interindividual polymorphism in restriction
fragment length and copy number of the TURI family of moderate human DNA
repetitions]. Biull Eksp Biol Med. 1987 Jan;103(1):57-8. Russian. PubMed PMID:
2879576.
90: Zaĭtsev IZ, Rogaev EI. [Structural analysis of alphoid DNA of primates. II.
Evolution and possible origin of alphoid DNA of primates]. Mol Biol (Mosk). 1986
May-Jun;20(3):674-82. Russian. PubMed PMID: 3014313.
91: Zaĭtsev IZ, Rogaev EI. [Structural analysis of alphoid DNA of primates. I.
Heterogeneity of nucleotide sequence of alphoid repeats in human DNA]. Mol Biol
(Mosk). 1986 May-Jun;20(3):663-73. Russian. PubMed PMID: 3014312.