Татьяна Татаринова. Анализ паттернов метилирования ДНК

ИОГен РАН, пятница 12 декабря 2014, в 11-00 в конференц-зале

---

Анализ паттернов метилирования ДНК

Татьяна Татаринова, PhD
Профессор школы медицины Кека, Университет Южной Калифорнии
Директор лаборатории вычислительной биологии,
Детский госпиталь, Лос-Анджелес (США).

The GC-content in the third codon position (GC3) exhibits a unimodal distribution in  many  plant  and  animal  genomes.  Interestingly,  grasses and  homeotherm vertebrates  exhibit  a  unique  bimodal  distribution. High  GC3  was  previously found to be associated with variable expression, higher frequency of upstream TATA boxes, and an increase of GC3 from 5' to 3'. Moreover, GC3-rich genes are predominant in certain gene classes and are enriched in CpG dinucleotides thatare potential targets for methylation. Based on the GC3 bimodal distribution we hypothesize  that  GC3  has  a regulatory  role  involving  methylation  and  gene expression. To test that hypothesis, we selected diverse taxa (rice, thale cress, bee, and human) that varied in the modality of their GC3 distribution and tested the association between GC3, DNA methylation and gene expression.

---