Аннотации статей. Том 62, 2026 г., № 6
Translated version (Russ J Genet. Volume 62, issue 6, 2026):
Izhoykina, E.V., Trifonova, E.A., Gavrilenko, M.M. et al.
Genetic Structure of Insufficient Fetal Growth: Analysis of Candidate Genes and Data from the Genome-Wide Association Studies.
DOI: 10.1134/S1022795426700158
Translated version (Russ J Genet. Volume 62, issue 6, 2026):
Fadeev, V.S., Silaeva, Y.Y., Dolmatova, D.M.
TLDc Family Genes Are Understudied but Promising Regulators of Protection against Oxidative Stress
DOI: 10.1134/S102279542670016X
Translated version (Russ J Genet. Volume 62, issue 6, 2026):
Khamiruev, T.N.
Coat Color Is the Genetically Determined Selection Trait in Horses (Equus caballus).
DOI: 10.1134/S1022795426700171
Translated version (Russ J Genet. Volume 62, issue 6, 2026):
Kucher, A.N., Nazarenko, M.S.
The Role of Genes Associated with Monogenic Forms of Thoracic Aortic Aneurysm and Hypercholesterolemia in the Formation of Comorbidity between Aortic Aneurysm and Atherosclerosis.
DOI: 10.1134/S1022795426700183
Translated version (Russ J Genet. Volume 62, issue 6, 2026):
Zuev, R.V., Krivoruchko, A.Y., Yatsyk, O.A. et al.
Search for RIMS2 Gene Polymorphic Variants Associated with Live Weight Parameters in Manych Merino Sheep Breed.
DOI: 10.1134/S1022795426700201
Translated version (Russ J Genet. Volume 62, issue 6, 2026):
Borisova, T.V., Cherdonova, A.M., Pshennikova, V.G. et al.
Analysis of the Origin of mtDNA Lineages Carrying the Pathogenic m.1555A>G Variant in the MT-RNR1 Gene, Causing Mitochondrial Form of Deafness in Eastern Siberia.
DOI: 10.1134/S1022795426700225
Translated version (Russ J Genet. Volume 62, issue 6, 2026):
Kislova, O.S., Ivenkov, M.P., Ulinova, A.O. et al.
Association of Polymorphism in the BBLN and SERF2 Genes Encoding Hero Proteins with the Risk of Age-Related Macular Degeneration.
DOI: 10.1134/S1022795426700237
Translated version (Russ J Genet. Volume 62, issue 6, 2026):
Filyushin, M.A., Seredin, T.M., Shchennikova, A.V. et al.
Relationship between the Expression of Ascorbate Synthesis and Recycling Genes and the Content of Ascorbate in Garlic (Allium sativum L.) Roots and Leaves.
DOI: 10.1134/S1022795426700249
Translated version (Russ J Genet. Volume 62, issue 6, 2026):
Gavrilenko, M.M., Trifonova, E.A., Babovskaya, A.A. et al.
The Role of the POLB Gene Alternative Splicing in the Fetal Growth Retardation Pathogenesis.
DOI: 10.1134/S1022795426700250
Статьи, опубликованные только в Russian J. of Genetics, № 6 – 2026 г.
Exploring the Causal Relationship between Gut Microbiota and Alzheimer’s Disease Based on Mendelian Randomization
Datong Third People’s Hospital, 037000, Shanxi Province, China
Correspondence to Zh. Cui
To investigate the potential causal relationship between gut microbiota (GM) and Alzheimer’s disease (AD) using Mendelian randomization (MR) approach. Genetic data from 18 340 individuals across 24 cohorts, collected by the MiBioGen consortium, were utilized. A total of 211 microbial taxa were initially identified; after excluding 15 taxa classified as ‘unknown,’ 196 were included in the batch analysis. Summary statistics for AD were extracted from a public GWAS database. Two-sample MR analysis was performed using the inverse-variance weighted (IVW) method, the weighted median method, and MR-Egger regression. Odds ratios (ORs) were calculated to estimate the causal effect of gut microbiota on AD. Heterogeneity and horizontal pleiotropy were assessed. A forest plot was generated to visualize the association between instrumental variable-related gut microbiota and AD risk. Four single nucleotide polymorphisms associated with gut microbiota were selected as instrumental variables. IVW results indicated that Desulfovibrio (OR = 1.0131, 95% CI: 1.0037 to 1.0224, P = 0.0059) and Defluviitaleaceae (OR = 1.0201, 95% CI: 0.999 to 1.0412, P = 0.0169) exhibited a positive causal effect on AD risk. Conversely, Slackia (OR = 0.9991, 95% CI: 0.9984 to 0.9999, P = 0.0259) and Lachnospiraceae NK4A136 group (OR = 0.999, 95% CI: 0.9982 to 0.9998, P = 0.0176) showed a negative causal effect on AD risk. Sensitivity analyses revealed no significant evidence of horizontal pleiotropy or heterogeneity. Conclusion: Gut microbiota plays a significant role in the pathophysiology of AD. The specific underlying mechanisms require further investigation.
DOI: 10.1134/S1022795426700195
К статье на сайте SpringerLink
The Genome Sequence of the Endemic Tavas Frog, Rana tavasensis Baran & Atatür, 1986 from Denizli, Türkiye
1 Animal Breeding and Genetic Research and Application Centre, Pamukkale University, 20160, Denizli, Türkiye
2 Department of Science Education, Faculty of Education, Pamukkale University, 20160, Denizli, Türkiye
3 Department of Biology, Faculty of Science, Pamukkale University, 20160, Denizli, Türkiye
Correspondence to A. Kaska
Amphibians are recognized as biological indicators of ecosystem health due to their sensitivity to environmental changes, and therefore genomic studies aimed at their conservation are becoming increasingly important. The genome assembly of the endemic Tavas Frog, Rana tavasensis has been obtained using the Oxford Nanopore Technologies (ONT) platform were assembled de novo using the Flye assembler. Where the completeness of the initial assembly was insufficient, scaffold refinement was performed using the RagTag tool via the reference genome of Rana temporaria, one of the closest species. Assembly quality was assessed using various structural metrics, and genome integrity was verified using Benchmarking Universal Single-Copy Orthologs (BUSCO) analysis. Large-scale structural variants detected in the genome were linked to gene annotations; variant-containing genes were functionally analysed using Gene Ontology (GO) terms. These analyses revealed significant differences from the reference species, particularly in biological processes related to immunity, development, and stress response. Furthermore, analyses performed using RepeatMasker identified numerous repeat classes, including Long Interspersed Nuclear Elements (LINE), Short Interspersed Nuclear Elements (SINE), Long Terminal Repeats (LTR), and DNA transposons, and their distribution within the genome was visualized. The number of variants were highest in the MHC2 (86.7 ± 15.9), MHY (79.4 ± 42.8) and HOX (53.45 ± 7.95) genes that were related to immune, muscular and developmental systems, respectively. This genomic resource is important for the understanding of the evolutionary and functional genomic characteristics of the species using the evaluations of structural variant analysis, functional annotations, and repeat sequences.
DOI: 10.1134/S1022795426700213
К статье на сайте SpringerLink