"Генетика", 2026 г., № 4

Статьи, опубликованные только в Russian J. of Genetics, № 4 – 2026 г.

Association of IL-12B (rs3212227) and IL-23R (rs11209026) Gene Polymorphisms with Psoriasis Susceptibility: A Systematic Review and Meta-Analysis

Praveen Kumar Chandra Sekar, Ramakrishnan Veerabathiran

Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Tamil Nadu, India
Correspondence to Ramakrishnan Veerabathiran

Polymorphisms in cytokine-related genes play pivotal roles in immune regulation and disease susceptibility. Psoriasis, a chronic immune-mediated skin disorder, is associated with variations in several interleukin genes. Among these, IL-12B (rs3212227) and IL-23R (rs11209026) are of particular interest because of their role in the Th17 signaling pathway. To clarify the relationship between these variants and psoriasis susceptibility, a systematic review and meta-analysis were conducted using data from case–control studies published up to May 2025. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under different genetic models using fixed- or random-effects methods. The analysis revealed that the IL-12B rs3212227 polymorphism was significantly associated with an increased risk of psoriasis, particularly among the Asian population, whereas the IL-23R rs11209026 variant showed a significant association in Caucasians. These findings suggest that IL-12B and IL-23R gene polymorphisms may contribute to ethnicity-specific genetic susceptibility to psoriasis. Larger population-based studies are required to confirm these associations and elucidate the functional mechanisms underlying these genetic effects.

DOI: 10.1134/S1022795425701728
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Genomic Characterization of TGA Transcription Factors in Gossypium Unravels WGD-Driven Functional Diversification in Development and Biotic Defense

S. Liang¹, M. Zhu^2,3, G. Yang³, Ch. Fu³, Ch. Lou¹, Y. Wang³, Zh. Lu¹, Yu. Luo¹, Y. Hu³, L. Xu^4,5, Y. Wang⁶, A. Abudurezike^4,5, Yu. Wu², X. Nie²

¹ Academy of Industry Innovation and Development, Huanghuai University, 463000, Zhumadian, Henan, China
² Key Laboratory of Oasis Ecology Agricultural of Xinjiang Production and Construction Corps, Agricultural College, Shihezi University, 832003, Shihezi, Xinjiang, China
³ National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, 430070, Wuhan, China
⁴ Institute of Crop Research, Academy of Agricultural Sciences of the Xinjiang Uyghur Autonomous Region, 830091, Urumqi, China
⁵ National Central Asian Characteristic Crop Germplasm Resources Medium-Term Gene Bank (Urumqi), 830091, Urumqi, China
⁶ Xinjiang Hexin Technology Development Co., Ltd., Shenzhen, China
Correspondence to A. Abudurezike or Yu. Wu, or X. Nie

TGA transcription factors, critical regulators of plant defense mechanisms, exhibit incompletely understood evolutionary dynamics and functional roles in the economically vital cotton genus (Gossypium). Genome-wide analysis of Gossypium hirsutum identified 32 GhTGA genes. Phylogenetic classification resolved four evolutionary clades, revealing significant lineage expansion primarily driven by whole-genome duplication (WGD), notably within Class IV. Conserved synteny analyses traced the polyploidization trajectory, while structural characterization detected ubiquitous DOG1 domains, bZIP domains in 16 members, clade-specific acquisitions (e.g., RVT_2 in GhTGA6), and conserved motifs. Promoter analysis revealed complex regulatory potential, featuring an abundance of light-responsive (GT1, G-box) and hormone-responsive cis-elements (predominantly ABREs), alongside extensive predicted transcription factor networks involving both conserved and lineage-specific regulators. Expression profiling indicated pronounced spatiotemporal specificity, with elevated transcript levels in developing vegetative organs and ovules (distinctly excluding Class II genes) but suppression in fibers and anthers. Crucially, key GhTGAs (e.g., GhTGA1, GhTGA4) exhibited marked upregulation under Verticillium dahliae stress, implicating their involvement in jasmonic acid/salicylic acid (JA/SA)-mediated defense. These findings provide valuable insights into the functions of GhTGAs and establish a foundation for cotton breeding programs.

DOI: 10.1134/S1022795425701777
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Chloroplast Genome Architecture of Trichosanthes kirilowii Maxim.: Structural Evolution, Repetitive Element Dynamics, and Comparative Phylogenetic Insights in Cucurbitaceae

Z. Z. Jiang^1,2,3, X. Y. Ge^1,2,3, Z. H. Yang^1,2,3, R. Y. Yuan^1,2,3

¹ Key Laboratory of Biodiversity Conservation and Characteristic Resource Utilization in Southwest Anhui, 246133, Anqing, China
² Anqing Forestry Technology Innovation Research Institute, 246133, Anqing, China
³ College of Life Sciences, Anqing Normal University, 246133, Anqing, China
Correspondence to Z. Z. Jiang

As a medicinally significant species within the Cucurbitaceae family, Trichosanthes kirilowii lacks comprehensive chloroplast genomic resources necessary for evolutionary and phylogenetic studies. In this study, we present its complete chloroplast genome: a circular DNA molecule measuring 156 924 bp, featuring a quadripartite structure with an LSC region (85 994 bp), an SSC region (18 334 bp), and two IRs (52 558 bp each). The genome contains 132 functional genes and exhibits a higher GC content in the IRs (43.01%) compared to the LSC (34.89%) and SSC (31.3%). We identified 198 long repeated segments and simple sequence repeat (SSR) motifs, mostly mononucleotide (A/T) variants. Codon usage strongly favors codons ending with A or U, particularly AGA and GAC. Comparative analysis across ten Cucurbitaceae species found conserved IR/SC boundaries, except in Cucumis melo (with divergent rpl2 positioning) and Lagenaria siceraria (with the complete loss of ndhF). Hypervariable regions, such as rps16 and the psbK-trnS spacer, along with non-coding spacers like trnQ-trnR, showed increased nucleotide diversity (Pi), in contrast with conserved IR regions. Evolutionary rate analysis showed predominant purifying selection (Ka/Ks ≤ 1). Phylogenetic reconstruction placed T. kirilowii in a distinct evolutionary clade, providing genomic foundations for molecular identification and biogeographic studies within Cucurbitaceae. This investigation establishes key chloroplast genomic resources and highlights mutation hotspots for future phylogenetic research.

DOI: 10.1134/S1022795425701790
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