Translated version (Russ J Genet. Volume 60, issue 2, 2024):
Bulanov, A.N., Voylokov, A.V.
Adaptive Significance and Origin of Flavonoid Biosynthesis Genes in the Grain of Cultivated Cereals.
DOI: S1022795424020029

 

 

Translated version (Russ J Genet. Volume 60, issue 2, 2024):
Kholina, A.B., Artyukova, E.V. & Sandanov, D.V.
The Evolutionary Pathways of Oxytropis Species of the Section Verticillares at the Center of the Section Origin
DOI: S1022795424020078

 

 

Translated version (Russ J Genet. Volume 60, issue 2, 2024):
Hantemirova, E.V., Radoukova, Tz.
Differentiation of Juniperus deltoidеs R.P. Аdams in the Crimean-Caucasian Region according to the Variability of Microsatellite DNA Markers
DOI: S1022795424020066

 

 

Translated version (Russ J Genet. Volume 60, issue 2, 2024):
Vinogradov, E.V., Karavaev, V.V., Balashov, D.A. et al.
On the Disappearance of the Pleiotropic Effect of the N Gene of the Scale Cover in Carp (Сyprinus carpio L.)
DOI: S1022795424020133

 

 

Translated version (Russ J Genet. Volume 60, issue 2, 2024):
Petrova, N.V., Marakhonov, A.V., Balinova, N.V. et al.
Study of the Karachay Population Based on the Analysis of Ten Polymorphic DNA Loci.
DOI: S102279542402011X

 

 

Translated version (Russ J Genet. Volume 60, issue 2, 2024):
Korovaitseva, G.I., Oleichik, I.V., Lezheiko, T.V. et al.
A Study of Association of the MIR137 VNTR rs58335419 with Schizophrenia.
DOI: S102279542402008X

 

 

Translated version (Russ J Genet. Volume 60, issue 2, 2024):
Malyarchuk, B.A., Derenko, M.V., Denisova, G.A. et al.
FADS Gene Polymorphism and the History of the Formation of the Indigenous Populations of Siberia
DOI: S1022795424020091

 

 

Translated version (Russ J Genet. Volume 60, issue 2, 2024):
Karandasheva, K.O., Makashova, E.S., Ageeva, F.A. et al.
Role of Molecular Genetic Factors in Formation of the Clinical Type of Neurofibromatosis Type 2.
DOI: S1022795424020054

 

 

Translated version (Russ J Genet. Volume 60, issue 2, 2024):
Zubareva, V.D., Bytov, M.V., Zaitseva, O.S. et al.
Development of Real-Time PCR Kits for Bovine Haplotypes HH3, HH6, HH7 Diagnosis.
DOI: S1022795424020145

 

 

Translated version (Russ J Genet. Volume 60, issue 2, 2024):
Gareeva, A.E.
Searching for Ethnospecific Risk Markers of Paranoid Schizophrenia in Bashkirs Based on the Results from Genome-Wide Association Study.
DOI: S1022795424020030

 

 

 

 

Статьи, опубликованные только в Russian J. of Genetics, № 2 – 2024 г.

Identification of Low Expression of GSN as a Key Prognosis Gene in Patients with Gastric Carcinoma

M. Hao, X. Zhang, Z. Li, S. Li, C. Li*

Department of Pathology, Affiliated Hospital of Chengde Medical College, 067000, Chengde, Hebei, China
Correspondence to C. Li

 

Gelsolin (GSN) is an important actin-binding protein. The current studyidentified the potential role of GSN in Gastric cancer (GC) tumorigenesis and prognosis using bioinformatic analysis. The TCGA, GTEx, and GEO databases were used to gain clinicopathological data on GC patients. Expression of GSN across cancers was evaluated. Kaplan–Meier analyses were conducted to evaluatethe prognostic value of GSN, while the association between GSN expression and clinical characteristics in gastric carcinoma was evaluated using the UALCAN database. The potential diagnostic value of GSN was assessed by the construction of ROC curves. The putative underlying cellular mechanisms were investigated by GO and KEGG pathway enrichment analyses. The GSN mRNA was validated by RT-qPCR. GSN mRNA and protein expression were lower in gastric carcinoma tissue than in noncancerous tissue. GO and KEGG enrichment analyses revealed that GSN plays a key regulatory role in actin binding and capping and thec-erbB/EGFR and PI3K/Akt signaling pathways. GSN has a high diagnostic significance, and low GSN expression is associated with shorter overall survival (OS) in gastric carcinoma. GSN expression was a risk factor for the progression-free interval in patients with gastric carcinoma. We observed that the OS rate of patients with higher GSN expression levels was longer, and GSN had significant predictive value for the clinical outcome of GC. GSN expression is involved in the tumorigenesis of gastric carcinoma progression and may regard as a putative diagnostic and prognostic biomarker for gastric carcinoma.

DOI: S1022795424020042
К статье на сайте SpringerLink

 

 

Genome-Wide Identification and Analysis of the CCoAOMT Gene Family Revealed Its Relationship to Pomegranate Seed Hardness

H.M. Suo, H.H. Ni, L. Hu, F.Y. Yuan, M.W. Zhang, S.M. Zhang*

Department of Ornamental Horticulture, School of Horticulture, Anhui Agricultural University, 230036, Hefei, Anhui, China
Correspondence to S.M. Zhang

 

Caffeoyl coenzyme A-O-methyltransferase (CCoAOMT) has a critical function in the lignin biosynthesis pathway. However, its role in pomegranate is not clear. In this research, we identified 11 members of the CCoAOMT gene family based on pomegranate genome-wide data. The 11 CCoAOMT genes were distributed non-uniformly on chromosomes 2, 3 and 4 of pomegranate. Phylogenetic analysis showed that pomegranate CCoAOMT9 and Camellia sinensis CCoAOMT genes clustered into one branch. Promoter cis-acting progenitor analysis revealed a role for the pomegranate CCoAOMT gene in the ABA/MeJA response. The expression of CCoAOMT8, CCoAOMT9 and CCoAOMT10 was higher in hard-seeded cultivars (‘Hongyushizi’ and ‘Baiyushizi’) than in soft-seeded cultivar (Tunisia) as detected and analyzed by q-PCR. The results suggested that CCoAOMT8, CCoAOMT9, and CCoAOMT10 might be related to lignin biosynthesis. The findings of this work provided a basis for further investigation of the role of the pomegranate CCoAOMT gene in lignin biosynthesis.

DOI: S1022795424020121
К статье на сайте SpringerLink

 

 

Investigating the Effect of Silica Nanoparticles on MMP9, HAS2, ITGAX, and Additional Key Genes: Implications for Enhanced Wound Healing

B. Mando¹, A. Al Athamneh², B. Alkhawaja³, C. Shannakian^4,5, A. Khaleel^1,*

¹ Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, 11104, Amman, Jordan
² Department of Nutrition, Faculty of Pharmacy and Medical Sciences, University of Petra, 11104, Amman, Jordan
³ Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences, University of Petra, 11104, Amman, Jordan
⁴ Department of Biology and Biotechnology, Faculty of Science, American University of Madaba, 17110, Madaba, Jordan
⁵ Farah Medical Campus, 11180, Amman, Jordan
Correspondence to A. Khaleel

 

Nanoparticles are an essential aspect of current scientific evolution, offering several potential applications in a number of fields. Particularly, in the therapeutic field such as in wound healing, the unique physical and chemical properties of silica nanoparticles (SiNPs) have attracted attention to it. In this study, we intend to investigate the relationship between silica nanoparticles and wound healing by analyzing altered gene expression before and after the treatment with (SiNPs), of 40 tissue repair related genes, giving special attention to (Matrix Metalloproteinase-9 (MMP-9), hyaluronan synthase 2 (HAS-2), integrin subunit alpha X (ITGA-X), integrin subunit alpha V (ITGA-V), integrin subunit alpha 5 (ITGA-5), S100 calcium binding protein A4 (S100A4), and vascular endothelial growth factor A (VEGFA)), to study the implications of these findings for better wound healing and to provide better insight into how SiNPs might be used to regenerate tissues and repair wounds. Our results showed that silica nanoparticles can significantly enhance wound healing by upregulating the expression of these key genes involved in the process.

DOI: S1022795424020108
К статье на сайте SpringerLink